Ugo Mayor

This study identifies HERC1 substrates through proteomic analysis, revealing its role in proteasome homeostasis and linking its dysfunction to neurodevelopmental disease.

This study identifies MYRF dysregulation as a mechanism linking Aβ pathology to oligodendrocyte and cognitive impairments in Alzheimer's disease, showing that PKC inhibition can restore myelin and cognition.

This study shows Fbxo42 promotes degradation of Ataxin-2 granules, enabling Xbp1 translation and triggering cell death during terminal UPR activation.

The paper demonstrates that BioE3 can identify endogenous substrates and neosubstrates of Cullin-RING ligases, revealing changes in the ubiquitination landscape upon molecular glue treatment.

BioE3 identifies substrates of UbL E3 ligases by site-specific biotinylation and proteomic analysis, revealing both known and novel targets for various E3 ligases.

This study identifies Comt/NSF as an ubiquitination substrate of Ari-1 in Drosophila neurons and shows that Ari-1 loss of function affects neurotransmitter release differently in spontaneous and evoked modes.