Sérgio Lilla

This study identifies BRK1 and CCDC53 as key subunits in WAVE and WASH complex assembly, showing their interaction with HSBP1 and their role in regulating actin dynamics and cell migration.

This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.

The paper identifies a conserved mechanism regulating mtDNA copy number through compartmentalization of redox co-factors across eukaryotes.

This study shows mouse and human macrophages use self-generated C5a gradients for chemotaxis, with distinct degradation mechanisms and optimal concentrations.

This study identifies NUAK1 as a regulator of alternative splicing in cortical neurons through phosphorylation of SON, linking it to neurodevelopmental processes and ZTTK syndrome.

This study shows that radiotherapy promotes lung metastasis in PDAC by increasing MRCK activity, which can be inhibited by BDP9066.

This paper develops a method to perform single-cell proteomics on preserved tissues, expanding its applicability by overcoming sample preservation challenges.

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.