Dhanendra Tomar

This study identifies IMS proteases as regulators of mitochondrial calcium transport by remodeling mtCU and NCLX through proteolytic control, linking proteostasis to Ca2+ homeostasis.

This study shows that reducing neuronal mitochondrial calcium uptake in AD mouse models decreases pathology, synaptic dysfunction, and cognitive decline.

This study identifies mitochondrial lactylation changes in myocardial infarction and shows that MCT1 inhibition alters lactylation, reduces fibrosis, and partially restores mitochondrial function.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study identifies TMEM65 as a regulator of NCLX-dependent mitochondrial calcium efflux, showing its role in preventing calcium overload and cell death in excitable tissues.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study identifies a novel mechanism by which GSK-3 promotes mitophagy in human cardiomyocytes under hypoxia through BNIP3 upregulation and interaction.