Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
L. Kuri-Cervantes, M. B. Pampena, W. Meng, A. M. Rosenfeld, C. A. G. Ittner, A. R. Weisman, R. Agyekum, D. Mathew, A. E. Baxter, L. Vella, O. Kuthuru, S. Apostolidis, L. Bershaw, J. Dougherty, A. R. Greenplate, A. Pattekar, J. Kim, N. Han, S. Gouma, M. E. Weirick, C. P. Arevalo, M. J. Bolton, E. C. Goodwin, E. M. Anderson, S. E. Hensley, , M. R. Betts
Abstract
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence SummaryBroad immune perturbations in severe COVID-19
02 /Specification & Classification
Click any tag to browse matching papersReproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets
S. Matic, S. Popovic, … D. Baskic·bioRxiv·Oct 9, 2020
- Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Feargal J. Ryan, Christopher M. Hope, … David John Lynn·BMC MedicinePeer-reviewed·Jan 13, 2022
- T cell activation, highly armed cytotoxic cells and a sharp shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19
O. Zenarruzabeitia, G. Astarloa-Pando, … F. Borrego·bioRxiv·Dec 22, 2020
- Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
A. E. Oja, A. Saris, … P. Hombrink·bioRxiv·Jun 18, 2020
- Long-term immune changes after COVID-19 and the effect of BCG vaccination and latent infections on disease severity
Kamila Bendíčková, Ioanna Papatheodorou, … Jan Frič·Clinical & Translational ImmunologyPeer-reviewed·Jan 1, 2025
- Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
A. J. Wilk, M. J. Lee, … C. A. Blish·bioRxiv·Dec 18, 2020