Author

J. Dougherty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Research Focus:host-pathogen & immune response· 6 Assay:flow cytometry· 5 Research Focus:differential expression· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. E. Baxter· 7 shared A. Pattekar· 7 shared A. R. Greenplate· 7 shared D. Mathew· 7 shared J. R. Giles· 7 shared O. Kuthuru· 7 shared E. J. Wherry· 6 shared S. E. Hensley· 6 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

A. E. Baxter

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

M. M. Painter, T. S. Johnston, K. A. Lundgreen, J. J. S. Santos, J. S. Qin, R. R. Goel, S. A. Apostolidis, D. Mathew, B. Fulmer, J. C. Williams, M. L. McKeague, A. Pattekar, A. Goode, S. Nasta, A. E. Baxter, , E. J. Wherry

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

bioRxiv · Feb 5, 2023 · PreprintImmunology

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

C. E. Gustafson, Z. Thomson, Z. He, E. Swanson, K. Henderson, M.-P. L. Pebworth, L. Y. Okada, A. T. Heubeck, C. R. Roll, V. Hernandez, M. D. Weiss, P. C. Genge, J. Reading, J. R. Giles, S. Manne, , P. J. Skene

The study identifies age-related differences in naive T cell compartments between children and adults, showing distinct molecular reprogramming in CD4 and CD8 subsets.

bioRxiv · Oct 4, 2022 · PreprintImmunology

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

R. R. Goel, M. M. Painter, K. A. Lundgreen, S. A. Apostolidis, A. E. Baxter, J. R. Giles, D. Mathew, A. Pattekar, A. Reynaldi, D. S. Khoury, S. Gouma, P. Hicks, S. Dysinger, A. Hicks, H. Sharma, , E. J. Wherry

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

bioRxiv · Feb 20, 2022Immunology

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

R. R. Goel, M. M. Painter, S. A. Apostolidis, D. Mathew, W. Meng, A. M. Rosenfeld, K. A. Lundgreen, A. Reynaldi, D. S. Khoury, A. Pattekar, S. Gouma, L. Kuri-Cervantes, P. Hicks, S. Dysinger, A. Hicks, , Set

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

bioRxiv · Aug 23, 2021 · PreprintImmunology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

bioRxiv · May 1, 2021Immunology

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

M. M. Painter, D. Mathew, R. R. Goel, S. A. Apostolidis, A. Pattekar, O. Kuthuru, A. E. Baxter, R. S. Herati, D. A. Oldridge, S. Gouma, P. Hicks, S. Dysinger, K. A. Lundgreen, L. Kuri-Cervantes, S. Adamski, , E. J. Wherry

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

bioRxiv · Apr 21, 2021 · PreprintImmunology

The translational landscape of SARS-CoV-2 and infected cells

M. Puray-Chavez, K. Tenneti, N. Lee, Y. Wang, H. R. Vuong, Y. Liu, A. Horani, T. Huang, S. P. Gunsten, J. B. Case, W. Yang, M. S. Diamond, S. L. Brody, J. Dougherty, S. B. Kutluay

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

bioRxiv · Nov 3, 2020 · PreprintMicrobiology

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

D. Mathew, J. R. Giles, A. E. Baxter, A. R. Greenplate, J. E. Wu, C. Alanio, D. A. Oldridge, L. Kuri-Cervantes, M. B. Pampena, K. D'Andrea, S. Manne, Z. Chen, Y. J. Huang, J. P. Reilly, A. R. Weisman, , E. J. Wherry

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

bioRxiv · May 20, 2020Immunology

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

L. Kuri-Cervantes, M. B. Pampena, W. Meng, A. M. Rosenfeld, C. A. G. Ittner, A. R. Weisman, R. Agyekum, D. Mathew, A. E. Baxter, L. Vella, O. Kuthuru, S. Apostolidis, L. Bershaw, J. Dougherty, A. R. Greenplate, , M. R. Betts

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

bioRxiv · May 18, 2020 · PreprintImmunology