biophysical modeling

The paper designs and evaluates D-amino acid-based peptides to inhibit SAA3 fibril formation in a mouse model of cardiac amyloidosis.

This study shows that geometric confinement affects ERK signaling and collective migration in epithelial tissues by altering mechanical states through actomyosin contractility.

This study identifies a new closure motif in SYCP2 and shows how HORMAD1 and HORMAD2 form a heterodimer, revising the model of mammalian meiotic axis assembly.

The paper infers enhancer-specific transcription factor interactions from gene expression data using a biophysical model and validates it with simulated and experimental data.

The paper links gene clusters in Floridanema to the production of β-amino polyketide residues, revealing shared biosynthetic architectures and evolutionary strategies.

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

This study identifies Flightless I and LRRFIP as regulators of lateral sarcomere growth in Drosophila flight muscle through actin filament integration at the Z-disc.

This study identifies respiratory complex I as a selective vulnerability in Francisella and shows that tolfenpyrad inhibits it with species-specific antibacterial activity.

The paper examines how the oral microbiome responds to high estradiol levels during ovarian stimulation, finding saliva tracks systemic hormone changes and Prevotella species exploit hormonal surges.

This study identifies subtype-specific biochemical properties of HIV-1C reverse transcriptase that enhance sequence motif duplication through improved strand transfer and mismatch extension.

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

This study defines the assembly pathway of a Tn7-like CAST, showing how DNA remodeling and TnsC positioning convert target recognition into directional transposition.

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

This study enhances cytosolic isobutanol and isopentanol production in yeast by introducing prokaryotic iron-sulfur cluster biosynthesis genes and accessory proteins.

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

The paper shows that lipid asymmetry drives pore formation in membranes, which function as self-resealing scramblases to restore balance.

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

This paper identifies FlcE as a flagellar collar protein in Borrelia burgdorferi that stabilizes the FliL-stator complex, enhancing motility and torque generation.

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

The paper identifies GCR1 as the sole GPCR in vascular plants through phylogenetic and bioinformatic analysis, suggesting its role in root hair function.

This study identifies RyDEP as an enzyme that degrades 2'cADPR and 3'cADPR immune signals, inactivating bacterial defense and restoring NAD+.

The paper identifies a bacterial NO-binding Cache_heme-HAMP receptor that interacts with a Ser/Thr kinase via conserved motifs, revealing a novel mechanism of NO signaling.

This study investigates NANOG's rheological properties, showing it forms self-limiting micelles that modulate DNA dynamics and may regulate gene expression through gel-like environments.

This study investigates FimH conformational dynamics and catch bond formation using a single-domain variant, revealing ultra-slow dynamics and a dynamic allosteric mechanism.

This paper shows that the mycobacterial ligand ManLAM uses structural features to engage TLR2 and Dectin-2, reprogramming macrophage lipid metabolism and promoting foam cell formation.

This study shows Rev1 inhibits Pol zeta activity on undamaged DNA but stimulates it at damaged sites, with the N-terminal M1 motif mediating this regulation.

This study shows that endogenous RALF peptides, perceived by FER and LLG-LRX complexes, are required for powdery mildew colonization of Arabidopsis, with RALF function influencing cell wall remodeling and apoplastic pH.