experimental assay

This paper develops a surface-engineering strategy for edible microcarriers that enhances cell adhesion without limiting material choice, showing improved cell attachment on multiple polysaccharides and cell types.

This study identifies CsrA as a global regulator of carbon preference and gut colonization in Acinetobacter baumannii, revealing its role in repressing arginine/ornithine catabolism and enhancing competitive fitness.

This study shows that HUS1 and RAD9 subunits of the 9-1-1 checkpoint clamp have opposing roles in shaping genome plasticity in Leishmania major through distinct replication-stress responses and genome remodelling patterns.

This paper develops a miniaturized traceless Staudinger ligation method to rapidly discover potent BRD4-targeting PROTACs by screening crude reaction mixtures directly in biological assays.

This study identifies sex-determining genes and links them to self-incompatibility in an androdioecious plant species.

The paper characterizes LOca-1, a calcium-activated arginyl-specific orthocaspase from Loki's Castle, showing its thermoactivity and structural conservation with plant metacaspases.

The paper examines how Drosophila simulans adapts to three new transposable element invasions through piRNA cluster insertions and finds that resistance evolves independently in different strains.

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

The paper examines gene expression patterns in isopod crustaceans to explore the developmental basis of pleopodal gill evolution.

This study identifies widespread oscillatory suppression in autism spectrum disorder across theta, alpha, and beta bands, confirmed in drug-naive patients.

This study investigates brain-body interactions during food anticipation using multimodal physiological recordings, finding distinct changes in gastric and cortical responses linked to appetite and craving.

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This study characterizes freshwater SAR11 HVR2 sequences, revealing high intra-population diversity and conserved functional configurations across marine and freshwater lineages.

This study shows that common dual-expression systems fail to balance WT and variant hERG expression, leading to inaccurate functional assessments of KCNH2 variants.

This study evaluates the combination of 5-FU with two triazoloacridinones, C-1305 and TRA-01AR, in CRC, finding that C-1305 shows greater antitumor activity while TRA-01AR has improved tolerability and vascular effects.

This study identifies an early physiologic calcification process in mouse tracheal cartilage and reveals MGP deficiency causes additional mucosal calcification, explaining respiratory symptoms in Keutel syndrome.

The paper identifies telotrons, telomeric repeat-containing introns, in multiple eukaryotic genomes and suggests telomerase drives intron creation and remodeling.

This study characterizes the virome of the West Coast blackfly, identifying novel viruses and revealing geographic structuring in viral communities.

This paper introduces a fibrous optofluidic probe for measuring blood oxygenation and flow velocity in vessels, demonstrating its use in rabbit and canine models.

This study reports cryo-EM structures of the 50S ribosome with EngA-bound GTPγS or GDP, revealing conformational changes in EngA and a novel SLJ motif during ribosome assembly.

The paper investigates how lifestyle-associated microbiome shifts and host genetics influence gene expression in intestinal organoids, identifying microbiome-dependent allele-specific expression effects.

This study shows that systemic TLR7 agonism reduces disease severity in DSS-induced colitis in mice by shifting the immune response toward regulatory T cells.

The paper screens FDA-approved compounds to find mitophagy activators, identifying Meptazinol and Ponatinib as top candidates that increase mitolysosomes but do not rescue bioenergetic defects in mitochondrial diseases.

The paper expands and evaluates the PedMan system to manage peacock eye disease across olive cultivars with different susceptibility levels, achieving high accuracy in fungicide recommendations.

This study investigates how ADP and magnesium influence the structural changes and higher-order assembly of peroxiredoxin 2, showing distinct roles in disassembly and reassembly processes.

The paper shows Rab10 and Arhgef7 interact to link vesicle transport and exocytosis, promoting axon extension by facilitating PPV insertion into the plasma membrane.

This study shows that combining multiple low-dose inhibitors targeting the same oncogenic driver can delay drug resistance in cancer models.

This study compares viral replication and host responses in airway epithelial cells to distinguish pathogenic from seasonal coronaviruses, finding HCoV-229E induces severe epithelial injury despite limited replication.