imaging

Three-dimensional T1 mapping demonstrates the transfer of oxygen into cerebrospinal fluid during hyperoxia

This study uses 3D T1 mapping to show oxygen transfer into cerebrospinal fluid during hyperoxia, revealing regional differences in oxygen diffusion dynamics.

An Open-Source, Excitation-Resolved UV-NIR Imaging Platform for Bioluminescence, Luminescence-Decay, and Chemical Discrimination Measurements

AURORA-MSI is an open-source multispectral imaging platform that enables excitation-resolved measurements of bioluminescence, luminescence decay, and chemical discrimination without photon-counting instrumentation.

oidyPeaks: R package for automated flow cytometry cell cycle analysis and visualization in fungal microbes

The paper introduces an R package for automated flow cytometry analysis of fungal cell cycle and karyotypic subpopulations, demonstrating its utility on evolving Candida albicans populations.

Brain representations of visual short-term memories during healthy human aging: occipital decline and frontoparietal compensation

This study investigates age-related changes in visual short-term memory using fMRI decoding, finding that visual cortex representations weaken with age and load, while frontoparietal regions compensate by strengthening during memory maintenance.

Interpretable Deep Learning of Endogenous Fluorophore Concentration and Entropy for Lung Tissue Classification

The paper uses an interpretable deep learning model to classify lung tissue as normal or cancerous by combining fluorophore concentration and entropy features, achieving high accuracy.

The first comprehensive case study of early-emerging prosopometamorphopsia

This paper presents the first comprehensive case study of early-emerging prosopometamorphopsia, detailing its clinical manifestations and neural correlates.

Tau-CTFP: A connectome-informed continuous-time first-passage model for forecasting the onset of regional tau PET abnormality

This paper introduces Tau-CTFP, a model for forecasting regional tau PET abnormality onset in Alzheimer's disease using connectome-informed continuous-time first-passage modeling, achieving high precision and recall in predicting abnormality onset.

Hierarchy of spindle forces in prometaphase

The paper analyzes 3D trajectories of chromosomes and spindle poles to reconstruct spindle forces in prometaphase, finding that pole-pole segregation is robust and primarily driven by interpolar forces.

Accelerating drug development in infectious diseases using zebrafish disease models supported by pharmacokinetic pharmacodynamic modeling as new approach methodology (NAM)

Zebrafish larva infection experiments plus pharmacokinetic-pharmacodynamic (PKPD) modelling gave bedaquiline's in vivo Emax and EC50 against M. marinum in about 2 months; waterborne clarithromycin barely entered larvae.

Shared Pain, Shared Decisions: How Empathy Shapes Social Conformity Through Physiology and Visual Attention

This study investigates how empathy influences social conformity through physiological arousal, visual attention, and socio-emotional traits using a combination of behavioral and physiological measures.

Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

Hexagonal modulation of theta rhythmic attentional sampling of visual space

The paper shows that visual attention samples space in a hexagonal pattern guided by theta rhythms, similar to spatial navigation mechanisms.

Associative learning reconfigures colour-guided behaviour in Drosophila larvae

This study shows Drosophila larvae can learn to avoid specific colors associated with electric shocks, demonstrating elementary color vision and the role of photoreceptor pathways in learned behavior.

Bivalent habenula modulation of human monoaminergic midbrain and cortical pathways

This study uses fMRI and dynamic causal modelling to show the habenula modulates midbrain and cortical pathways with both inhibitory and excitatory effects during negative reward prediction error tasks.

Keratin 17 Defines an Epithelial-Mesenchymal Transition-Associated Migratory Cell State in Pancreatic Ductal Adenocarcinoma

This study identifies K17 as a marker of an EMT-associated migratory cell state in PDAC, showing its role in promoting tumor-cell migration and poor prognosis.

Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration

Region-stratified scRNA-seq of 607,370 cells plus 500-gene MERFISH maps adult Danionella cerebrum cell types body-wide, revealing fibroblast Hox and limb-identity programs and telencephalon regeneration dynamics.

Integrated luminescence and phenotypic profiling for drug discovery in a zebrafish model of Marfan syndrome

This study uses a zebrafish model of Marfan syndrome to identify potential therapies through a high-throughput drug screen and luminescence-based phenotyping.

CountAnywhere: frugal cell counting and viability from smartphone hemocytometer photos

CountAnywhere provides a smartphone-based tool for accurate and efficient cell counting and viability assessment using hemocytometer images.

In Utero MRI of Radial Glial Fibers Highlights Their Role in Modulating Fetal Cortical Folding

This study uses in utero MRI and computational models to show that radial glial fibers influence fetal cortical folding through biomechanical modulation.

Revealing multiscale architecture of the intact human spine using hierarchical phase contrast tomography

This paper uses HiP-CT to image the human spine at high resolution, revealing multiscale anatomy and microstructural features without exogenous contrast.

Revealing the benefit of eye motion for acuity under emulated cone loss

The paper shows that eye motion compensates for cone loss in vision, maintaining acuity even with significant cone cell reduction.

A crown story: How tree architecture drives maple syrup yields

This study identifies crown structure and growth characteristics as key predictors of maple syrup yield, explaining up to 47% of inter-individual variability in syrup production.

Quantifying the role of hyaluronic acid on collagen fiber mechanics via femtosecond laser ablation

This study uses femtosecond laser ablation to measure collagen fiber recoil in tendons, showing that hyaluronic acid (HA) is critical for fiber sliding and mechanical properties.

Adaptation of Iterative Ultrastructure Expansion Microscopy (iU-ExM) enables high-resolution imaging of the cytoskeleton and subcellular architecture of Trypanosoma cruzi

The paper introduces an optimized iU-ExM protocol for high-resolution imaging of T. cruzi cytoskeletal structures and subcellular architecture using conventional confocal microscopy.

OocystMeter, a machine-learning algorithm to count and measure Plasmodium oocysts, reveals clustering patterns in the Anopheles midgut

OocystMeter automates oocyst counting and sizing in mosquito midguts, revealing clustered spatial patterns in malaria infections.

How goals shape naturalistic memories: bias in gaze and narrative recall

This study shows how induced goals shift attention during memory encoding and bias narrative recall in a naturalistic setting.

Multimodal epi-mode 3D quantitative phase and fluorescence microscopy enables supervised volumetric virtual fluorescence in bulk tissue

This paper introduces a multimodal microscope that uses a cGAN to generate virtual fluorescence images from phase contrast data, enabling virtual histological staining of bulk tissues.

Open Blink: Low-cost TIRF microscopy for super-resolutionimaging via μManager

Open Blink provides a low-cost, open-source TIRF microscope for quantitative multi-color super-resolution imaging with high localization precision and axial stability.

Distributed brain-spinal cord dynamics during micturition revealed by functional ultrasound imaging

This study uses functional ultrasound imaging to map brain and spinal cord activity during micturition in rats, revealing region-specific hemodynamic responses and decoding bladder pressure dynamics.

Data-driven gait cycle decomposition based on whole-body coordination dynamics

This study decomposes gait cycles using a dynamic system framework to identify coordination patterns in human locomotion.