mouse

This study shows that deleting Stim1/Stim2 in microglia reduces calcium signaling but leads to larger infarct sizes after ischemic stroke, suggesting CRAC signaling protects brain tissue.

This study shows that L-selectin shedding regulates neutrophil mobilization after heart attack but does not affect heart damage or remodeling.

This study shows that oligodendroglial dysfunction in an ASD model leads to hypomyelination, circuit dysfunction, and social deficits, with early treatment restoring these features.

The paper identifies a short nucleophosmin isoform that links nucleolar remodeling to DNA damage repair during meiosis by interacting with γH2AX.

This paper introduces Volumetric Cross-Amplitude Modulation (VxAM) for 3D transcranial gas vesicle imaging, demonstrating improved contrast through ex vivo mouse skulls.

This study compares the distribution of an EGFR-targeted antibody and affibody in pancreatic tumors relative to collagen using synchrotron diffraction, finding cetuximab shows stronger inverse correlations with collagen than ABY029.

This study shows that light power density during photodynamic therapy determines systemic antitumor effects by influencing singlet oxygen generation, tumor perfusion, and circulating extracellular vesicles.

This study investigates actin reorganization and junctional remodeling in podocyte foot process effacement using advanced imaging techniques and shows reversible changes in actin and slit diaphragm proteins during nephrotoxic serum nephritis.

This study develops a tetravalent dengue mRNA vaccine that induces broad, durable, and protective immunity across all four serotypes in mice.

This study uses PET imaging to track CCR2+ monocyte and macrophage infiltration in arthritis, showing correlation with disease severity and structural changes.

The paper uses in vivo imaging to show PACAP38 preferentially dilates dural vessels and identifies this as a measurable therapeutic target for migraine treatments.

This paper provides a detailed protocol for implementing Mini2P calcium imaging in freely moving mice, covering system setup, optical alignment, and behavioral integration to study neural activity during natural behavior.

This study compares two basal forebrain subnuclei in mice, showing they have distinct connectivity and functional recruitment patterns that lead to different cholinergic effects on the cortex.

This paper introduces a behavioral paradigm to study anticipatory postural adjustments in mice and identifies the PRN as a candidate node in the circuitry supporting these adjustments.

The paper introduces FluoCode, a fluorescent barcoding system for multiplexed projection mapping in mice and marmosets, revealing fine-scale topographic maps in subcortical regions.

This paper introduces evidence-based re-identification to correct tracking mistakes in multi-animal behavior studies, showing improved reliability over time compared to existing methods.

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

The paper develops SA-eGRASP to map and track potentiated synapses in the mouse hippocampus following learning and uses it to study long-term synaptic dynamics.

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

This paper uses multimodal imaging to link molecular identity with nanoscale 3D cell morphology in opossum cortical cultures, showing how molecular changes correlate with morphological differences during development.

The paper uses imaging and modeling to study transient leaks in epithelial tight junctions, finding that dynamic strand breaking and sealing explain leak behavior at the junction level.

This study shows that callose-dependent coordination between cell division and growth is essential for planar morphogenesis in moss phyllids.

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

This study uses sparse eGFP labeling to compare astrocyte morphology across brain regions and sexes in mice, finding sex-dependent and region-specific changes after early-life stress.

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

This paper develops a RIG-I reporter mouse model to track RIG-I expression and function in vivo, revealing its tissue distribution and identifying alveolar macrophages as key sensor cells.

This study examines neural responses in mouse visual cortex to natural and artificial visual stimuli, finding increased activity in response to natural mismatches but no change in dendritic-somatic coupling.

MorphoProt predicts spatial protein abundance using RNA expression, multiscale histology, and tissue neighborhoods, outperforming baselines in human and mouse tissues.

ClearGel enables chronic, near-millimeter two-photon imaging through the intact skull in live mice with high resolution and reversibility.