cell-cell communication

The paper develops a spatial proteomics workflow to study early astrocytic remodeling in an ALS mouse model, finding that motor neurons are surrounded by GFAP-high environments earlier than previously observed.

This study shows that therapeutic anti-IgE antibodies form immune complexes with distinct functional properties, influenced by allergen incorporation and receptor binding patterns.

SPARK quantifies phage-antibiotic interactions using growth curves and shows synergy, antagonism, and dynamic changes across bacterial isolates and time.

This study demonstrates the transferability of homoserine lactone sensors between Bacillales bacteria, enabling programmable interphyla communication between Gram-negative and Gram-positive species.

This study shows mutant IDH1 increases sEV secretion and alters their cargo composition in glioma and chondrosarcoma cells, with D2HG packaged into sEVs and cell-type-specific cargo remodeling.

CauloBrowser 2.0 updates the systems-biology database for Caulobacter crescentus with AI-powered tools for querying and visualizing experimental data.

The paper identifies clonally convergent Tfh/Tph-like CD4+ T cells that persist in the mucosa after recovery from periodontitis and contribute to recurrence.

The paper investigates how different humanized tau isoforms and mutations affect synaptic connectivity and interact with mitochondrial proteins in cortical neurons.

This study investigates plant-plant communication in tomato by analyzing metabolomic and volatile emissions changes in response to herbivory, showing mirror effects in immune system reprogramming between sender and receiver plants.

This study identifies VLC fatty acyl-ceramides as essential for endocytic invagination by interacting with endocytic machinery and ORPs.

The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.

This paper develops a method to predict seabird-vessel interactions using only seabird telemetry data, showing high accuracy but limitations in distinguishing fishing from nonfishing vessels.

This study shows that IFI16 filament assembly provides mechanical stability to condensates by compacting DNA into ultra-stable tangles, contrasting with the sensitivity of HIN200-dsDNA complexes.

This study identifies INMT's localization near the Golgi apparatus in human neurons and suggests it creates a region for psychedelic tryptamine biosynthesis.

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

GraphExperiment provides an R/Bioconductor package to store and manipulate high-dimensional quantitative data alongside associated networks in a unified framework.

The paper uses a multi-modal platform to profile single-cell stress responses in human cell lines, finding a shared stress response program with cell-specific magnitude variations.

The paper examines proximal podomere patterning in sea spiders and arachnids, finding homoplastic evolution of gene expression patterns that challenges assumptions about leg segment homology.

This study identifies Gαq as a regulator of mitochondria-lysosome contact dynamics, showing its role in mitochondrial fragmentation and quality control through interactions with Fis1 and RabGAPs.

This study shows TRPM7 kinase activity modulates pathogenic TH17 cell differentiation and function, with reduced TRPM7 activity leading to milder EAE and increased Tregs in mice.

The paper uses an adapted anipond technique to identify changes in nuclear protein associations with host and viral genomes during HSV-1 infection, revealing redistribution of key cellular factors.

This study identifies Vago4 as a ligand that downregulates Domeless to restrain JAK/STAT signaling in invertebrates, defining an IFN-like axis.

This study identifies Tie1, a fungal effector that targets OsTLP7 to suppress plant immunity by altering its localization and transcriptional activity.

This study shows lung cancer stem cells adapt to the brain microenvironment through neuro-mimetic reprogramming and epigenetic changes, enabling metastasis.

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

The paper investigates how a bacterial chaperone-usher pathway enables interkingdom protection of a fungus from antimicrobial compounds.

This study shows that KIF1A-mediated lysosomal transport into axons is regulated by the axon initial segment microtubule environment, and its disruption leads to axonal degeneration.

This study shows blue light exposure reduces pluripotency and increases neuronal differentiation in Müller glial cells from chicken retinas.

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

The paper assesses Zymoseptoria tritici candidate effectors in Nicotiana benthamiana to identify immune recognition and potential host-independent activities, finding that expression timing and signal peptides influence effector phenotypes.