differential expression

Renal adaptation to primary aldosteronism requires GDF15 to control plasma potassium level in mice and human.

This study shows GDF15 helps mice and humans maintain potassium levels by promoting intercalated cell proliferation in response to aldosterone excess.

General Purpose AI for Public Data Analysis and Experimental Hypothesis Generation

The paper demonstrates how general-purpose AI can analyze public molecular datasets to generate hypotheses and identify biological relationships, though not all findings were validated experimentally.

N-Acetylglucosamine ameliorates knee osteoarthritis by enhancing UDP-GlcNAc conversion and chondrocyte DNA repair capacity

This study compares N-acetylglucosamine (GlcNAc) and glucosamine hydrochloride (GlcN·HCl) in a rat model of knee osteoarthritis, finding GlcNAc more effective in reducing inflammation, cartilage degradation, and promoting DNA repair.

Using Arabian Sea Coastal Water as a Model to Study Plasmid-mediated AMR Dissemination driven by Anthropogenic Impacts

The paper studies AMR dissemination in Arabian Sea coastal waters, identifying diverse plasmid replicons and clinically relevant antibiotic resistance genes linked to anthropogenic stressors.

Systematic Functional Interrogation of Neurodevelopmental Disorder Risk Variants

This study identifies 38 expression-modulating variants associated with neurodevelopmental disorders and links them to neurodevelopmental transcriptional programs using MPRA and CROP-seq.

Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model

This study shows that mitochondrial dysfunction contributes to premature musculoskeletal aging in HCH mice, with proteomics revealing altered aging trajectories and bone fragility.

LMNA Haploinsufficiency in Human iPSC-Derived Cardiac Organoids Reveals Early Fibrotic Signaling as a Therapeutically Targetable Process

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

Small-molecule ACOD1 inhibition attenuates colitis and tumor growth through a shared myeloid mechanism, diverging from genetic deletion

This study shows that ACOD1 inhibition reduces colitis and tumor growth via a shared myeloid mechanism, differing from genetic deletion effects.

ResponseVerdict overturns computationally validated immunotherapy signatures, recovers their missed responders and outperforms every published response predictor

ResponseVerdict improves immune checkpoint blockade response prediction by outperforming existing signatures and predictors using data from prior studies.

Study on The Effect of a Propiconazole Based Fungicide on Plant Growth Promoting Properties of Isolates from Wheat Rhizosphere

This study examines how propiconazole affects six plant growth promoting properties of wheat rhizosphere isolates, finding that specific traits like siderophore and ammonia production are suppressed at high concentrations.

Extracellular Vesicles Derived from L-MYC Neural Stem Cells Mediate Neuroprotection in 3D Models of Chemotherapy- and Radiation-Induced Neurotoxicity

This study uses a 3D neural tissue model to show that extracellular vesicles from L-Myc neural stem cells promote recovery from chemotherapy- and radiation-induced neurotoxicity by modulating inflammatory and stress pathways.

Insulin-binding B cells can arise in early-stage type 1 diabetes individuals in the absence of somatic hypermutation or insulin autoantibody seropositivity

The paper identifies anti-insulin B cells in early-stage T1D patients without autoantibodies or somatic hypermutation, showing their role in autoimmunity.

Decoding Cell-level Circadian Phase and Rhythm-state Remodeling in Single-cell Transcriptomes With scRhythmBayes

scRhythmBayes infers cell-level circadian phase and rhythm-state remodeling in single-cell transcriptomes, revealing distinct temporal patterns in liver zonation and heart disease.

The PGC-1α Gly482Ser rs8192678 SNP reprograms oxidative metabolism to favor energy storage in females

This study shows that the PGC-1α Gly482Ser SNP reprograms oxidative metabolism to favor energy storage, especially in females, through reduced respiratory capacity and altered metabolic responses.

Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophages

This study shows that Myo1e/f regulate phagocytic podosomes and the phagocytic ring to ensure efficient cup closure in macrophages.

Immune surveillance at plasmodesmata restricts the movement of a fungal effector

The paper identifies ChEC108 as a fungal effector that targets plasmodesmata in Arabidopsis, binds HIPP6, and induces plasmodesmal closure to restrict fungal spread.

Common and Sex-Biased Muscle Transcriptomic Aging Signatures Across Diverse Species

The paper identifies common and sex-biased aging biomarkers in skeletal muscle transcriptomes across six species, revealing shared and divergent molecular mechanisms of aging.

Dopaminergic Medication Improves Force Control and Modifies Motor Unit Activity During the Steadiest and Least Steady Periods in Parkinsons Disease

This study shows dopaminergic medication improves force steadiness and reduces motor unit variability in Parkinson's disease during both steady and least steady contraction periods.

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer

The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.

Longitudinal analysis of vaccine-associated alterations in the faecal microbiota of layer chickens using a vaccination schedule representative of commercial practice

This study examines how multiple vaccines affect the gut microbiota of layer chickens over time, finding stable microbial diversity and composition despite vaccination.

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties

The paper uses DNA methylation profiling to identify distinct subsets within rhabdomyosarcoma subtypes, revealing clinical and genetic differences among them.

SPATNIC enables H&E-grounded cancer-cell identification across spatial and single-cell transcriptomic modalities in colorectal cancer

SPATNIC is a variational autoencoder that identifies cancer cells from spatial and single-cell transcriptomic data in colorectal cancer, outperforming existing tools and identifying a rare cancer stem cell population.

TRUEDA overturns replicated, decontaminated low-biomass disease-microbe associations and clinical decisions, recovers true pathogens and outperforms every decontamination method

TRUEDA identifies true pathogens in low-biomass disease-microbe associations by accounting for contamination, outperforming existing decontamination methods and correcting false associations.

Contribution of the Late Positive Potential to Emotional Memory: A Joint Neuro-Cognitive Approach to Memory Prediction

The paper investigates how the late positive potential (LPP) relates to memory for emotional items, finding that early LPP predicts memory for emotional items but not neutral ones.

Macrophage-Derived 25-Hydroxycholesterol Drives Statin-Associated Acute Kidney Injury

This study shows that macrophage-derived 25-hydroxycholesterol increases susceptibility to statin-induced acute kidney injury by impairing autophagy and promoting cell death.

Chromatin states coordinate diurnal gene expression in the Drosophila retina

The paper shows that chromatin states, not just circadian transcription factors, coordinate diurnal gene expression in Drosophila photoreceptor neurons by aligning gene phases with promoter, enhancer, or repressive chromatin signatures.

KRT7CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.

Circulating extracellular vesicles display immunotherapeutic targets and complement circulating tumor DNA in high-risk neuroblastoma

The paper identifies tumor-associated surface markers on circulating extracellular vesicles as complementary biomarkers to circulating tumor DNA in high-risk neuroblastoma.

Neuro-Metabolic and Vascular Dysregulation are Functional Biomarkers of Acquired Brain Injury

The paper evaluates neuro-metabolic and vascular dysregulation in mice post-TBI, finding sex- and injury side-dependent changes that suggest MVD as a potential biomarker.