T-cell and B-cell Immunology

The paper identifies gene regulatory modules in thymic regulatory T cells to prioritize variants in complex diseases and uncover mutational hotspots.

This study identifies transcriptionally distinct naive CD4+ T cell subsets in mice and humans using scRNA-seq, showing their functional diversity and environmental responsiveness.

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

The paper reports the crystal structure of the THEMIS CABIT2 domain, revealing a novel fold with an inserted SH3-like domain and insights into its interaction with GRB2.

This study shows that CXXC1 interacts with FOXP3 to regulate Treg cell function and epigenetic stability, essential for immune homeostasis and preventing inflammation.

The paper investigates how nanoscale clustering and density of activating and costimulatory antibodies influence T cell activation, finding that global density is more critical than cluster size.

This study shows PKC theta sustains T cell function while PKC eta drives terminal exhaustion, with distinct downstream cascades and therapeutic implications for cancer immunotherapy.

This study identifies TMX1 as a critical regulator of T cell function by modulating CD3zeta stability and TCR signaling.

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.

This paper introduces a modified Fab'-DNA ligand to study TCR signal integration by controlling kinetic on- and off-rates, revealing how dwell time affects TCR signaling and LAT condensation.

The paper identifies age-associated TCR repertoire components using a new computational framework and links them to immune aging and clinical outcomes.

This study shows that low pH impairs CD8+ T cell function by reducing IL-2 responsiveness, disrupting mTORC1 signaling, and altering c-Myc levels and amino acid metabolism.

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

This study introduces CITR-seq, a method for single-cell TCR sequencing, and shows genetic factors significantly shape TCR repertoires in mice.

The paper compares TCR loci in mice and related species, finding recent contraction in the variable gene cluster in Mus musculus castaneus and expression of atypically oriented variable genes.

The paper develops and validates the tviblindi algorithm to identify branching developmental trajectories in human B cell development using mass cytometry data.

This study identifies TIA1 and TIAL1 as key regulators of T cell quiescence by controlling the expression of transcription factors that restrain homeostatic proliferation.

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

This study shows that increased EZH2 activity in regulatory T cells enhances their effector differentiation and autoimmunity suppression capacity.

The paper identifies that a combination of surface antigen density and internal nucleic acids is sufficient to initiate strong antiviral IgG responses without T cell help or Toll-like receptor signaling.

The paper develops a flow cytometry method to analyze T cell receptor Vβ and phenotype simultaneously, identifying long-lasting CMV-related T cell expansions with consistent TIGIT and PD-1 expression.

The paper introduces the OTS database, a curated resource of paired-chain TCR sequences, and develops a language model for analyzing TCR pairings and coherence.

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

This study identifies IRF5 as a key regulator of T cell effector function through mTORC1 signaling, glutamine metabolism, and post-transcriptional control following TCR activation.

The paper investigates how sequence variations in LAT affect T cell activation pathways and identifies conserved motifs critical for function.

This study shows that p53 suppresses thymic NKT17 cell development by responding to DNA damage signals, with p53 loss increasing NKT17 numbers and DNA damage response.

The paper uses live-cell imaging to study TCR:pMHC interactions in anti-viral and autoimmunity settings, revealing differences in synaptic engagement, CD8 co-engagement, and signaling efficiency that define central tolerance boundaries.

The paper examines how TCR performance differs under physical force, finding digital TCRs are more effective in vivo.

The paper shows that mild detergent exposure reactivates retroelements, inducing CD8+ T cells that enhance skin wound repair through IL-17A.