T-cell and B-cell Immunology

This paper develops a murine vaginal epithelial organoid system that supports CD8 T cell differentiation into resident memory T cells in vitro, showing phenotypic and transcriptional similarity to in vivo TRM.

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

This study shows PD-1 inhibits Th2 cell differentiation and allergic inflammation in mice, suggesting its therapeutic potential for Th2-driven diseases.

The paper tracks GC-derived B cells in lymph nodes to identify PrePC cells and their transition to plasma cells, revealing spatial and transcriptional changes during differentiation.

This study establishes thymic epithelial organoids that mimic in vivo thymus function and support T cell development in vitro.

The paper shows that initial TCR signal strength sets early expression of GATA3 and Tbet, influencing Th2 differentiation, while cytokine signals modulate later differentiation outcomes.

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

This study shows that Id3 deficiency affects the development of gamma delta T cell subsets by regulating the generation and function of the Vgamma1Vdelta6.3 TCR.

This study investigates the role of B-1 cells in CD8 T lymphocyte cytotoxicity against Encephalitozoon cuniculi in mice, finding reduced activating molecule expression in B-1 deficient mice but enhanced cytotoxicity after prior infection.

This study shows that T cell responsiveness to IL-10 determines the effectiveness of costimulation blockade therapy in transplant models, impacting graft survival.

The paper identifies TMN CD4+ T cells that persist after YFV vaccination and contribute to long-term immunological memory.

The paper investigates how IL-4 from therapeutic or helminth-induced sources affects bystander activation of CD8 T cells, showing it modulates cytotoxic mediator expression without fully blocking the process.

The paper shows that CD8+ T cells with stronger TCR signals in NOD mice are more pathogenic in diabetes, suggesting they are targets for treatment.

This study shows Akt2 deficiency impairs Th17 differentiation, enhances Th2 differentiation, and reduces peripheral immune responses to immunization.

This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.

This study shows that increased PI3Kδ activity in Tregs disrupts their function and homeostasis, leading to immune dysregulation and autoimmunity in mice.

This study shows TGFβ profoundly regulates T-cell size and physiology by modulating gene expression and transcription factor networks, independent of other cytokines.

The paper identifies cytokine combinations that enhance the expansion of stem cell-like memory T cells and links them to follicular helper T cell differentiation.

This paper develops a multiscale spatial simulation framework to model the germinal center response, recapitulating key molecular, cellular, and morphological events.

This study shows that CD3ζ enhances TCR surface expression and function in human T cells by increasing endogenous TCRβ expression and reducing mispairing with endogenous chains.

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

The paper investigates the epigenetic mechanisms enabling T-follicular helper cells to transdifferentiate into TR1 cells, finding that TR1 gene programs are pre-established in TFH cells.

This study profiles longitudinal proteomic and phosphoproteomic changes in CD8 T cells during acute and chronic infections, identifying exhaustion-associated proteins and phosphosites with potential therapeutic relevance.

This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.