Influenza Virus Research Studies

This paper introduces FluAdaX, a deep learning framework to predict influenza A virus cross-species transmission potential using genomic data, identifying key genes and variants associated with host adaptation.

This study demonstrates that the anti-M1 monoclonal antibody 2B-B10-G9 effectively neutralizes influenza A virus subtypes by binding to conserved M1 epitopes and suppressing virulence gene expression.

This study investigates how influenza A virus morphology affects entry kinetics and cell-to-cell spread, finding that filamentous viruses spread more slowly and are advantageous under neutralizing antibody pressure.

This paper develops a vaccine candidate using DIOSvax-H5inter nanocages that elicits cross-clade neutralising antibodies and T cell responses against diverse H5 influenza strains.

This study shows influenza A viruses induce tunnelling nanotube-like structures through apoptosis to spread between cells, evading immune responses.

The paper develops a replicating recombinant vesicular stomatitis virus expressing H5N1 influenza glycoproteins to study viral resistance and antibody escape without biocontainment constraints.

This study evaluates BECC adjuvants' ability to enhance HA-based influenza vaccine efficacy in mice, showing improved immune responses and viral clearance.

This paper develops an in vitro aerosol exposure system to study influenza virus infectivity in different cell types and identifies differences in airborne infectivity among virus strains.

The paper compares a miniaturized on-site platform with benchtop instruments for detecting inactivated H5N1 avian influenza virus in raw milk, finding the miniaturized platform more sensitive.

This study compares two H9N2 avian influenza lineages, finding the G57 genotype has higher replication, virulence, and transmission fitness in chickens than the G1-B lineage.

This study shows that IFITM3 knockout mice are a viable preclinical model for testing influenza vaccines due to their enhanced viral replication and functional immune responses.

FluWarning detects emerging influenza A virus spillovers using codon bias and dinucleotide composition anomalies, identifying pdm09 and B3.13 genotypes before their spread.

This study introduces mudRapp-seq to visualize influenza A viral RNA transcription and replication at the single-cell level, revealing early mRNA expression and differential segment expression.

This study compares the tissue tropism of two HPAI H5N1 isolates in mice, finding that the bovine isolate replicates in the brain and causes more neurotropism and inflammation than the human isolate.

This study investigates the pathogenicity and transmissibility of a bovine-derived HPAI H5N1 B3.13 virus in pigs, finding susceptibility but limited replication and no transmission.

This study introduces SAASI, a method that improves ancestral state inference by accounting for sampling bias, and demonstrates its effectiveness in reconstructing H5N1 virus transmission in the US.

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

The paper identifies 2,3-linked sialic acids in the mammary glands of pregnant dairy heifers, suggesting susceptibility to H5N1 influenza virus infection.

The paper characterizes glycoproteins of novel fish influenza B-like viruses, revealing differences in receptor binding and antigenic conservation compared to influenza B viruses.

This study evaluates the antiviral and immunomodulatory effects of H84T BanLec on human immune cells and IAV-specific CD8 T cell responses.

The paper develops a cross-reactive influenza vaccine using a rare Ad6 vector that protects against clade 1 and 2 H5 viruses in mice and ferrets.

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

This study uses single-molecule microscopy to investigate influenza A virus-induced nanoscale cellular changes at the virus-cell interface, revealing receptor dynamics and actin cortex responses.

This study shows that bat influenza A virus H18N11 attaches to MHCII clusters on host cells, causing local clustering of MHCII molecules similar to immunological synapse formation.

This study reports H5 HPAIV causing high mortality in skuas in Antarctica, highlighting risks to their populations and potential role in virus spread.

This study identifies a reassortment event in wild birds leading to HPAI A(H5N1) infection in cattle and highlights the risk of virus spread through asymptomatic cattle to humans.

The paper identifies conserved sites on influenza H1 and H3 hemagglutinin recognized by human antibodies and characterizes their neutralization potential and escape pathways.

This study uses an in vitro model and mathematical modeling to quantify fitness parameters of HPAI clade 2.3.4.4 viruses in chicken and duck cells.

This study shows that influenza virus infection causes reduced immune cell counts and impaired differentiation in the thymus and bone marrow, linked to systemic inflammation and oxidative stress.