Circadian rhythm and melatonin

The paper constructs a single-cell atlas of mouse intestinal immune cells across the day-night cycle, revealing circadian dynamics in gene expression and cell populations.

This study shows that increased neuronal activity can restore circadian function in Drosophila models of C9orf72-ALS/FTD.

BayCT detects circadian biomarkers and estimates molecular circadian time in human brain transcriptomes, outperforming existing methods by jointly addressing both tasks.

This paper develops a functional human retinohypothalamic tract assembloid to study circadian rhythms, showing synchronized network activity and self-sustained gene expression oscillations.

The paper identifies a circadian circuit linking the SCN to the mPFC that regulates social prioritization through Vipr2 signaling in the RE.

The paper develops a minimal three-gene model of the hepatic circadian clock in mice that accurately captures temporal expression profiles and predicts synchronizing mechanisms.

CCorGsDB identifies clock-regulated genes in mouse and human CNS regions using co-expression networks and circadian biomarkers, providing disease and drug target information for chronopharmacological research.

This paper identifies novel clock activators, chlorhexidine and CM002, that suppress adipocyte development and hypertrophy, leading to anti-obesity effects in mice.

This paper uses phylogenomic analysis to examine sleep-related genes in LUCA, finding conserved genes linked to signaling, metabolism, and circadian rhythms, suggesting their fundamental role in evolution.

The paper shows that AVP neurons in the SCN oscillate with a short period, and VIP signaling adjusts this to generate a 24-hour rhythm, highlighting a feedback loop essential for circadian robustness.

This study examines how light affects hypothalamic activity in adolescents and young adults across different times of day, finding stable regional responses with developmental differences in magnitude.

This study shows the liver clock regulates transcriptional rhythms in skeletal muscle, affecting mitochondrial function through endocrine communication.

PyCycleBio models non-sinusoidal-oscillator systems in temporal biology, offering improved sensitivity and uncovering new relationships between data modalities and rhythmic behaviors.

TimeTraits extracts functional traits from biological time-series data using Functional Data Analysis methods, applied to circadian clock bioluminescence in Arabidopsis.

This study shows that hepatocyte circadian clocks regulate cholesterol metabolism and protect against MASH, with Bmal1 playing a specific role in this process.

This study identifies direct SCN-hippocampal projections and shows chronic circadian disruption causes memory impairment through network desynchronization.

This study investigates how photoperiod and temperature cues influence developmental checkpoints in the moth Loxostege sticticalis, revealing a shifting hierarchy of environmental time cues over ontogeny.

The paper identifies non-canonical circadian oscillators in Drosophila neurons that exhibit molecular rhythms despite lacking core clock genes.

This study examines how sex and age affect circadian and infradian rhythms in mice, finding sex- and age-specific differences in activity patterns and physiological responses to isolation.

This study identifies a bidirectional relationship between the SAGA complex deubiquitinase module and the molecular circadian clock, showing mutual regulation of their activities.

This study shows that feeding cycles, not direct circadian clock control, drive most metabolic rhythms in Drosophila, even though metabolic gene expression is locally clock-regulated.

This study links circadian rhythm distinctness to academic performance using login data, finding moderate rhythmicity correlates with highest performance and varying effects by chronotype.

This study shows that melanopsin expression and its role in circadian photic responses differ between male and female mice.

This study links circadian period variation to phenological traits in Boechera stricta across elevational gradients and common garden experiments.

This study identifies Dio3 expression as essential for setting the period of circannual interval timing in Djungarian hamsters through transcriptomic analysis and CRISPR-Cas mutation.

This study shows that a human BSX variant in mice disrupts circadian behavior and food anticipation but preserves lifespan and metabolic homeostasis.

easyClock is a user-friendly desktop application for circadian rhythm analysis and visualization, offering batch processing and multiple analysis methods without coding expertise.

This study compares light exposure and behaviour in Switzerland and Malaysia, finding cultural and geographical differences in light exposure patterns and the relationship between self-reported and objective measures.

The paper investigates the YMC phase transitions by integrating metabolic, chromatin, and transcriptional data, finding that metabolite accumulation mediates the shift between HOC and LOC phases.

The paper reveals that post-biting behavioral reprogramming in Aedes aegypti mosquitoes involves circadian clock-dependent changes that enable nocturnal egg-laying and reproductive efficiency.