Circadian rhythm and melatonin

The paper shows that Drosophila clock neurons capture circulating neuropeptide vesicles in anticipation of release, independent of axonal expansion or calcium signaling.

The paper identifies lithocholic acid as a bile acid metabolite that modulates circadian rhythms in intestinal cells by affecting core clock proteins and feedback loops.

This study shows melatonin reduces neurobehavioral issues and hippocampal inflammation caused by diet and photoperiod changes.

This study investigates the role of usherin in zebrafish sleep regulation, finding altered sleep-wake behavior in ush2a mutants despite normal circadian rhythms and melatonin release.

The paper develops auxiliary data frameworks and quality control strategies for wearable light loggers to improve data accuracy and interpretability in circadian research.

This study shows that GABA from AVP neurons disinhibits VIP neurons to regulate circadian activity/rest time through indirect suppression of intermediate GABA neurons.

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

The paper quantifies the kinetic hierarchy of Kai protein complex formation in cyanobacteria, revealing distinct assembly dynamics that regulate the circadian oscillator.

This paper identifies NaR as a liver clock-controlled metabolite that links circadian rhythms to adipogenesis via the prefoldin complex and UPR signaling.

This study shows that circadian phase and sex influence swimming behavior and physiological responses in mice, with rest-phase exercise causing weight loss and stress markers.

This study identifies infradian heart rate rhythms in healthy adults using wearable data, finding common multiday patterns and links to environmental and hormonal factors.

This study analyzes the evolution of Drosophila circadian clock proteins across 65 species, finding high divergence in some genes and no strong constraints on their evolution.

This study identifies and localizes circadian clock neurons in Antarctic krill using immunostaining and in situ hybridization, revealing PDH-positive neuron clusters and core clock gene expression.

This study compares SCN network dynamics in diurnal and nocturnal mice, finding species-specific differences in molecular clock rhythms and spatial timing organization.

This study shows that daytime light intensity influences sex differences in sleep and circadian regulation in mice, with brighter light reducing vulnerability to nighttime light.

This study investigates the role of biological clocks in controlling shell biomineralisation in M. galloprovincialis, finding evidence of an endogenous rhythm in biomineralisation-related gene expression.

This study shows that chronotype skew arises from stochastic sleep homeostasis interacting with circadian rhythms, not directly from circadian period distribution.

The paper introduces THERM-D, a machine learning tool to analyze body temperature rhythms in Drosophila, revealing that CRY-negative clock neurons regulate morning temperature rise independently of evening rhythms.

The paper evaluates ICT prediction methods using single samples and finds ZT outperforms models, but TimeSignature can surpass ZT with additional predictors.

This study shows that phototransduction mutations in Drosophila disrupt day sleep, indicating visual input promotes sleep.

dlmoR implements the hockey-stick method for DLMO estimation, showing high agreement with existing methods and revealing algorithmic limitations.

The paper shows that WCC dephosphorylation in Neurospora sustains circadian rhythms without new WCC synthesis, highlighting phosphorylation as key to the circadian oscillator.

This paper identifies MOR-containing SWI/SNF foci as perinuclear scaffolds that gate chromatin accessibility for circadian gene regulation, revealing a spatial mechanism for converting protein oscillations into transcriptional rhythms.

This study shows that aging in Drosophila retina causes broad epigenetic shifts, including decreased histone methylation, which disrupt gene expression rhythms despite a functional circadian clock.

The paper identifies intrinsic circadian clocks in spinal dorsal horn and dorsal root ganglia, revealing temporally structured molecular programs and circadian modulation of pain-related genes.

This paper uses mathematical modeling to show that bistability in dendritic cell homing, regulated by the circadian clock, explains time-of-day-dependent immune responses to vaccines.

This study shows human and non-human primate sleep timing is synchronized with lunar and solar gravitational cycles, independent of light exposure.

This study uses spatial transcriptomics to show that Alzheimer's disease disrupts circadian rhythms in specific brain regions before amyloid plaques form in a mouse model.

The paper identifies translational regulation of GAD1 in the mouse SCN using Ribo-seq and RNA-seq, showing light-induced ribosome binding without mRNA changes.