Lipid Membrane Structure and Behavior

The paper investigates how lipid organization in nanodiscs affects GPCR conformational states, finding that anionic lipid concentration thresholds vary between POPS and POPG.

The paper measures membrane fluidity in Gram-positive bacteria across temperatures and finds fluidity is maintained at low temperatures but not at higher temperatures.

This study identifies anionic bacterial sphingolipids, specifically ceramide phosphoglycerate, and shows they increase membrane zeta potential and stiffness.

This study shows that membrane curvature and lipid composition together influence oxidation rates in lipid bilayers, with curvature increasing oxidation and cholesterol modulating this effect.

The paper investigates how fusion peptides from enveloped viruses mediate membrane fusion in model cell membranes using microfluidic devices and fluorescence microscopy.

This study investigates how ATP and ADP binding affects MreB polymerization and membrane interaction in Geobacillus stearothermophilus, revealing distinct binding affinities and membrane fluidizing effects.

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

The paper shows that lipid asymmetry drives pore formation in membranes, which function as self-resealing scramblases to restore balance.

The paper introduces a single vesicle fluorescence microscopy platform to quantify phospholipid scrambling by VDAC1 dimers and opsin, revealing kinetic heterogeneity in scrambling rates.

This paper shows that membrane lipid composition and asymmetry determine whether a CPP translocates or causes leakage, using simulations and experiments.

This study introduces a DNA-based nanodisc scaffold for membrane protein assembly, demonstrating its compatibility with various lipids and detergents.

This paper studies DNA nanomotifs anchored to lipid bilayers, showing they undergo two-dimensional phase separation based on sticky end interactions, independent of lipid phase separation.

This study compares membrane structural properties across different system sizes and hydration levels, and evaluates four analysis software tools for their performance and consistency.

This study investigates how 4,4'-DNPA, a carotenoid in S. aureus, affects membrane biophysical properties, showing it increases membrane order and stability compared to STX.

This study uses high-throughput simulations to analyze transmembrane helix partitioning in lipid membranes, finding most peptides prefer the disordered phase and some localize at the interface.

This paper introduces DNA-templated peptide-DNA conjugates that form defined lipid nanodiscs with controlled structure and peptide arrangement.

This study quantifies interleaflet coupling in asymmetric lipid bilayers and observes anti-registered phases in 14:1-PC systems.

This study shows that TamB transfers lipids through a hydrophobic groove connecting inner and outer membranes in Gram-negative bacteria, with lipid release dependent on TamA binding.

The paper presents a dynamic NMR lineshape simulation framework for lipid diffusion and membrane thinning in bicelles and nanodiscs, enabling accurate interpretation of anisotropic NMR spectra.

This study shows phospholipase D (PLD) reduces lipid and protein diffusion in membranes by producing phosphatidic acid, which affects phosphoinositide signaling and membrane protrusion.

This paper introduces dynaMIET, a method to measure 3D membrane dynamics in live cells, and shows it can track lateral diffusion and vertical fluctuations simultaneously.

The paper quantifies amino acid side-chain insertion energetics in a POPC bilayer using unbiased molecular dynamics simulations and derives potentials of mean force to characterize bilayer partitioning.

This study investigates the structural role of PRPH2 and Rom1 in photoreceptor outer segment disk curvature using BN-PAGE and MD simulations, revealing their interaction web and curvature mechanisms.

This study models the structure and simulates the membrane binding and pore formation mechanism of PfPLP1, revealing how it interacts with host cell membranes and forms pores.

This study investigates the interaction of myristoylated GRASP65 and GRASP55 with lipid membranes using reconstitution and various analytical techniques, revealing their impact on membrane dynamics.

This paper introduces DNA-Lipid Nanodiscs (DLNs) with a PEG interface to study membrane proteins and lipid bilayers, showing effective shielding of hydrophobic mismatch through PEG-lipid interactions.

This study develops and validates coarse-grained models of mycobacterial outer membranes to investigate lipid organization and PDIM behavior under different lipid environments.

This study identifies S-acylation and oligomerization as key factors controlling HIR2 plasma membrane targeting and nanodomain organization in Arabidopsis.

The paper investigates how budding yeast septin filaments affect the mechanical properties of giant unilamellar vesicles (GUVs), finding that large GUVs become more deformable while small ones become less deformable due to septin-induced membrane reshaping.

The paper examines how lysophospholipid headgroups and acyl chain properties affect yeast vacuole fusion, Ca2+ transport, and acidification.