Microtubule and mitosis dynamics

This study shows that excluding condensin I from the nucleus during prophase allows condensin II to complete sister chromatid resolution, ensuring correct chromosome segregation.

This study examines FOXM1 dynamics in single cells under various perturbations, identifying six distinct cellular phenotypes and showing how FOXM1 behavior influences cell cycle outcomes.

The paper identifies CCSer2 as a protein that gates dynein activity at the cell periphery by inhibiting its regulator Ndel1, enabling spatially restricted dynein activation.

This study shows HIV-1 Vif causes a pseudo-metaphase arrest by reducing PP1 and PP2A at kinetochores, distinct from Vpr-induced prometaphase arrest.

The paper identifies RNA-dependent proteins in cell division using R-DeeP, revealing new interactions and phosphorylation events involving AURKA, KIFC1, and TPX2.

This study identifies PP2A-B56 as a phosphatase that regulates Mid1 protein levels, ensuring proper cytokinesis in fission yeast by preventing asymmetric division.

This study develops optimized, reversible cell cycle synchronization methods for human RPE1 cells to investigate stage-specific regulatory mechanisms.

This study shows that Plk1 inhibition delays mitotic entry, revealing prophase-specific phosphoproteome changes and highlighting Plk1's role in the prophase to prometaphase transition.

The paper identifies a meiosis-specific pericentromere specification in Peromyscus mouse oocytes that separates sister-chromatid cohesion from the kinetochore.

This study investigates how ion concentration affects BimC's function by analyzing electrostatic interactions between BimC and microtubules using molecular dynamics simulations.

This study screens natural compounds to identify those affecting cell and chloroplast division in Chlamydomonas reinhardtii, finding that curcumin disrupts chloroplast division without affecting microtubule structures.

This study identifies Alms1a and Alms1b as regulators of centriole duplication in Drosophila by enabling the Plk4-Ana2 amplification loop and Sas-6 recruitment.

The paper introduces an optimized AID system for reversible and sustained protein degradation in live mice, demonstrating its effectiveness in degrading CEP192 and causing cell division failure.

The paper investigates how different cargo adaptors influence the kinetics and mechanism of dynein-dynactin complex formation, revealing distinct assembly pathways and stable tripartite complexes.

This study identifies N2G as an F-actin bundler and kinesin-1 activator that mediates active microtubule-actin crosstalk, crucial for nuclear positioning.

This study determines the structure of the ch-TOG-TACC3 interaction and shows that inhibiting it causes pericentriolar material fragmentation and delayed mitosis.

The paper introduces a catalytic growth model for centrosome size regulation, showing it achieves robust size equality across organisms.

This study shows DCX regulates neuronal branching by promoting tubulin polyglutamylation, with loss of DCX leading to reduced polyglutamylation and increased neurite branching.

This study shows that centromeric chromatin is mechanically resilient and distinct from pericentromeric chromatin, which deforms under force, with CCAN components not affecting pericentromere stretching.

This study shows NuMA acts as a dynein adaptor, stabilizes microtubule minus ends, and facilitates their transport to spindle poles, with γTuRC hindering NuMA binding.

The paper identifies adaptation strategies in aneuploid cancer cells through in vitro evolution and multi-omics analysis, revealing key transcription factors and genomic changes that improve proliferation and survival.

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.

This study shows that Mis4 is essential for proper nuclear separation in fission yeast after quiescence, with implications for human diseases involving NIPBL.

This study identifies multiple CCAN binding sites and shows that FACT localization to kinetochores depends on specific CCAN subcomplexes and is regulated by CK2 phosphorylation and DNA displacement.

This study shows that cells lacking Bub3, a spindle checkpoint protein, retain specific chromosomes through aneuploidy, which provides a survival advantage by increasing the expression of genes involved in chromosome segregation.

This study identifies three mechanisms that maintain mother-daughter centriole engagement and describe how structural changes enable their disengagement during mitosis.

This study identifies Kinesin12-II as a motor protein essential for transporting cell plate materials to the phragmoplast midzone in moss, revealing its role in cell plate formation and gametophore development.

The paper identifies an Aurora kinase A-BOD1L1-PP2A axis that promotes chromosome segregation fidelity in cancer cells and shows its role in resistance to a MCAK agonist.

The paper shows LIN-5/NuMA regulates spindle orientation and tissue organization in C. elegans germ cells through polarized cortical localization.

The paper shows that separated N- and C-terminal parts of Ana1 can rescue centriole duplication but not elongation, highlighting distinct functional requirements for Ana1 in these processes.