Autophagy in Disease and Therapy

This study identifies a CDKL5/SINTBAD/TBK1 signaling pathway that regulates autophagy and protein aggregate clearance in neurons, showing that CDKL5 deficiency impairs this process.

This study investigates age-related mitochondrial impairments and mitophagy defects in human neurons using direct reprogramming and imaging.

This study shows reverse transcriptase inhibitors induce autophagy in cancer cells through LINE-1 ORF1p-dependent mechanisms involving DNA damage and lamin B1 interactions.

This study shows that lysosome-related organelle genes are necessary for mitochondrial remodeling during bacterial infections in C. elegans and drive downstream infection-response gene expression.

This study identifies PP2A and CDK16 as regulators of WIPI2B phosphorylation and neuronal autophagosome biogenesis, showing their antagonistic roles in this process.

The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.

This study identifies a novel STING-induced pathway involving LRRK2 that drives pericentrosomal positioning of acidic organelles through the VAIL-LRRK2-Rab35 mechanism.

This study identifies MOSPD3 as an adaptor that recruits ATG2A to the ER, facilitating autophagy by mediating direct interactions between ATG2A and the ER.

The paper screens a proteome-wide peptide library to identify LC3B binding determinants, revealing exceptions to the canonical LIR motif and highlighting sequence features that influence binding affinity and specificity.

This study shows Gp78 ubiquitin ligase regulates omegasome formation and mitochondrial protein degradation during mitophagy, independent of PINK1 and Parkin.

This study identifies PCDH17 as a regulator of lysosomal function that modulates autophagy attenuation during prolonged starvation.

This study shows that activating Beclin1 prevents aldosterone-induced cardiovascular damage by restoring autophagy, protecting vascular and cardiac function.

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

This study identifies ribosomal proteins as major substrates of starvation-induced endosomal microautophagy in Drosophila, revealing its role in metabolic adaptation.

This study shows that glutaminase (GLS) mediates Myc-induced autophagy in Drosophila wing discs and links Myc-dependent glutamine metabolism to non-autonomous autophagy in RasV12-transformed epithelia.

This study develops AZM derivatives that maintain anti-inflammatory effects while allowing autophagy, reducing resistance risk.

This study identifies RUBCN variants in neurodevelopmental disorders and shows they cause autophagy overdrive, leading to neurodegeneration.

The paper identifies a lipid transfer-dependent feedback loop that activates ATG9A compartments during autophagy initiation by enhancing ATG2A-mediated lipid transfer and ATG8 lipidation.

This study shows that BCL2L13 downregulation in NSCLC promotes metastasis by impairing mitophagy and enhancing epithelial plasticity and anoikis tolerance.

The paper identifies PQLC2 as a lysosomal pH regulator that affects tau homeostasis through a CRISPRi screen in iPSC-derived neurons.

This study identifies Atg1-mediated phosphorylation of Atg2 as a mechanism to activate lipid transfer during autophagosome biogenesis.

This study identifies a lipid-triggered allosteric site in LC3 that modulates receptor binding activity through conformational changes upon membrane engagement.

The paper investigates how different forms of autophagy restrict neurite outgrowth in distinct neuronal compartments in C. elegans neurons.

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

This study shows the SARS-CoV-2 E protein disrupts ER calcium homeostasis via SERCA inhibition, leading to autophagy-related membrane remodeling.

This study identifies the mechanism by which Atg11 recruits Atg9 in yeast selective autophagy through structural and biochemical analysis.

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

This study identifies autophagy-inducing 2,5-diketopiperazines (DKPs) that do not suppress mTORC1, revealing stereochemistry's role in their activity.

This study shows autophagy coordinates carbon/nitrogen ratios with developmental transitions in Physcomitrium patens by modulating auxin responses and cell-type-specific plasticity.