Autophagy in Disease and Therapy

This study investigates how BDNF regulates axonal autophagy and finds that BDNF stimulates autophagic flux but does not appear to carry signaling information through autophagosomes.

The paper shows USP30 inhibition enhances mitophagy and reduces oxidative stress in parkin-deficient neurons, with non-dopaminergic neurons being the main受益者.

The paper identifies hnRNP R as a nuclear RNA binding protein that inhibits autophagy by interacting with key autophagy proteins and shows depletion of hnRNP R activates autophagy flux.

The paper investigates the relationship between influenza virus-induced autophagy and MUC1 expression in cancer cells, finding that autophagy markers and MUC1 are upregulated in influenza-positive cells.

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

The paper identifies probucol as a mitophagy enhancer through AI-guided screening, showing it improves dopaminergic neuron survival in models of mitochondrial damage.

The paper shows how EndophilinA couples calcium influx to synaptic autophagy and identifies a Parkinson-risk mutation that disrupts this process.

This study shows that increasing autophagy in Drosophila female germline stem cells delays aging but can lead to cell death if sustained, with E-cadherin playing a key role in maintaining stem cell niche interactions.

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

This study shows that PALB2 maintains redox and mitochondrial homeostasis in the brain and works with ATG7 to prevent p53-dependent neurodegeneration.

The paper identifies the molecular mechanism by which vault RNA1-1 regulates p62 oligomerisation, essential for selective autophagy.

This study shows G9a/GLP methyltransferases inhibit autophagy by methylating and degrading ATG12, but their degradation under stress allows ATG12 accumulation and autophagy activation.

This study identifies mGlu1 receptor's role in regulating neuronal autophagy and shows FEZ1 mediates this regulation by linking mGlu1 to Ulk1.

The paper identifies small molecules that modulate nuclear LC3, rescuing cells from docetaxel-induced nuclear stress.

This study shows that RORα regulates mitophagy via caveolin-3 in cardiomyocytes, preserving mitochondrial function and preventing cardiac hypertrophy.

This paper identifies Rab2 as a target for enhancing autophagy in Parkinson's disease models, showing improved neuronal function and lifespan.

This study shows that EBOV-trVLPs induce autophagy via CMA, and HSC70, HSPA1A, and HSP90AB1 are required for this process.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

This study shows that long-term synaptic depression triggers local autophagic vesicle biogenesis in dendrites, which is essential for synaptic remodeling and cognitive flexibility.

The paper investigates the genetic interaction between ATG1 and UCC1 in S. cerevisiae, showing synthetic growth defects and sensitivity to genotoxic agents.

The paper uses immunohistochemistry to study Ser65-pUb distribution in mouse hippocampus, finding reduced levels in PINK1-deficient mice and partial colocalization with neuronal markers.

This study uses live imaging and mathematical modeling to analyze ATG13 dynamics in non-selective autophagy and mitophagy, revealing distinct patterns of translocation and their relationship to mitochondrial fragment size.

The paper shows lysosomal cystine efflux limits TORC1 reactivation during fasting by restricting amino acid availability through TCA cycle intermediates.

The paper shows that mTOR suppresses autophagy in the striatum during postnatal development, with autophagic flux reaching adult levels by P28.

This study uses light-induced ROS to control SV protein damage and shows that autophagy rapidly clears damaged proteins in mouse hippocampal neurons, maintaining synaptic function.

This study shows that patient-derived PRPS mutations in Drosophila cause autophagy and lysosome dysfunction, leading to sensitivity to nutrient deprivation and oxidative stress.