Bacterial biofilms and quorum sensing

This study shows that bacterial colonies form serpentine 'cables' in polymer-rich environments due to entropic attraction and hindered diffusion, revealing new principles of morphogenesis in complex media.

This study identifies synergistic combinations of quorum-sensing inhibitors and antibiotics to combat antibiotic-resistant bacteria, finding that piperacillin with ketoprofen, indomethacin, and piroxicam shows broad antimicrobial action.

This study identifies an active quorum sensing pathway in Vibrio coralliilyticus that regulates virulence factors like proteases, biofilms, and type VI secretion systems.

This study shows that the biofilm matrix, particularly EPS and TasA fibers, protects Bacillus subtilis against hydrogen peroxide, with sporulation playing a minor role.

This study shows that pseudopaline-mediated zinc uptake in Pseudomonas aeruginosa enables clinically relevant phenotypes and influences infection outcomes.

This study shows that c-di-GMP is required for swarming motility in E. coli, with DgcO promoting colanic acid production, which has surfactant properties aiding surface navigation.

This study shows that Vibrio cholerae biofilms undergo surface remodeling and inversion of cell-matrix interactions, shifting from attractive to repulsive as biofilms age, which facilitates dispersal.

This study shows human cell-derived extracellular vesicles reduce Pseudomonas aeruginosa biofilm formation, with effectiveness observed across multiple cell sources.

This study examines Pseudomonas aeruginosa in chronic wounds, finding recurring genotypes with minor phenotypic and SNP differences, suggesting adaptation to the host environment.

The paper investigates biofilm formation in ammonia-oxidizing archaea, finding distinct colonization strategies and shared gene expression patterns related to biofilm growth.

This study identifies beneficial microbial strains that form positive biofilms to exclude harmful bacteria and shows that compatibility control is needed in synthetic community design.

This study shows that amino acid uptake and leakage rates determine microbial community structure and composition in synthetic E. coli consortia.

The paper characterizes avirulent P. aeruginosa strains lacking T3SS genes, showing they produce variable secondary metabolites despite low cytotoxicity.

The paper investigates how bacterial toxin production and Allee effects influence predator-prey dynamics between Pseudomonas fluorescens and amoebae, revealing spatiotemporal regulation of toxin production.

This study shows that absence of two biofilm adhesins in Desulfovibrio vulgaris Hildenborough affects surface attachment and cell strategy, with distinct roles compared to other bacteria.

This study investigates the role of surfactin in pellicle biofilm formation in B. subtilis, finding that surfactin deletion delays pellicle formation, which is rescued by exogenous surfactin.

This paper shows that Enterococcus faecalis reduces Pseudomonas aeruginosa's production of quinolone signals and pyocyanin through ornithine, enabling mutualistic survival in co-culture.

This study shows that long-term hypoxia exposure leads to stable phenotypic and proteomic changes in Pseudomonas aeruginosa, similar to those observed in chronic CF lung infections.

This paper shows that the conserved regulator H-NS has strain-specific effects on biofilm formation in Vibrio fischeri, with different strains showing varied phenotypes when hns is disrupted.

This study investigates the resilience and charge-dependent fibrillation of Pseudomonas amyloids FapB and FapC, revealing their complex interactions and implications for biofilm persistence and potential applications.

The paper shows that ExsA regulates the Fem system in Pseudomonas aeruginosa, linking it to virulence factors and affecting pathogenicity in vivo.

This paper develops tools to study Pseudomonas aeruginosa infection and biofilm formation in vivo using C. elegans, identifying RhlR as a potential antimicrobial target.

This study identifies NahK as a regulator of denitrification and NO accumulation in P. aeruginosa, linking it to cell morphology changes through RsmA.

This study identifies genes essential for Pseudomonas aeruginosa aggregate formation in CF sputum using RNA-seq and microscopy, revealing distinct spatial phenotypes and cooperative interactions.

This study identifies two new low molecular weight compounds, C1 and C2, produced by Lactiplantibacillus plantarum SJ33 that exhibit antibacterial and anti-biofilm activity against Klebsiella pneumoniae.

This study shows that serotype switching in Pseudomonas aeruginosa ST111 from O4 to O12 enhances adhesion, motility, and virulence in murine pneumonia.

This study uses far-red fluorogenic probes to reveal single-cell dispersal patterns in Vibrio cholerae biofilms, showing that dispersal starts at the periphery and 25% of cells never disperse.

The paper identifies RetS as a bacterial adrenergic receptor in P. aeruginosa that responds to norepinephrine and dronedarone, modulating virulence and pathogenesis.

This study develops BaSSSh-seq, a bacterial single-cell RNA sequencing method, to analyze transcriptional heterogeneity and immune responses in biofilms.

This study uses expansion microscopy to differentiate adhesive interactions between microbial cells in biofilms at the single-cell level.