Cellular transport and secretion

This study identifies RHBDL4 as a protease that remodels cargo receptor networks, modulating secretory pathway flux by cleaving ERGIC cargo receptors and affecting lysosomal protein secretion.

This study identifies STX3 in human RPE cells and shows its role in tight junction assembly, challenging previous assumptions about its absence and functional compensation by STX1A.

This study identifies RAB35's role in regulating endo-lysosomal dynamics during apicosome formation in a human epiblast model.

This study identifies Copine-6 as a protein that links calcium, phosphoinositide, and Rab11 signals to regulate glutamate receptor recycling in neurons.

The paper investigates SNARE-mediated ER-Golgi fusion, showing that a specific SNARE topology is required for efficient fusion and that COPII components inhibit fusion by sequestering SNAREs.

This study identifies a lipid-gated vesicular trafficking pathway for HSPA1A to the plasma membrane via the endo-lysosomal network, highlighting lysosomal BMP and endosomal PI(4)P as regulatory factors.

The paper shows that β-adrenergic signaling inhibits MHCII surface deposition in reactive astrocytes via amisyn, reducing exocytosis of lysosome-like vesicles.

This study shows that SEPTIN 9 and ESCRT protein depletion reduces plasmid expression by impairing endosomal escape and autophagy pathways.

This study shows clathrin alone can drive membrane fission in vitro, with stronger assembly leading to weaker fission, suggesting lattice curvature, not just recruitment, drives membrane remodeling.

This study shows RAL-1 regulates the Exocyst complex in C. elegans, affecting secretion and development through direct interactions and genetic perturbations.

This study uses optical tweezers to measure SNARE complex intermediates and energetics during membrane fusion, revealing how membrane forces, lipids, and regulatory proteins control the process.

This study identifies a cleavable signal peptide in TMEM165 essential for its Golgi targeting and membrane topology, showing that N-terminal deletions restore function and suggest the signal peptide's role in biogenesis.

This study identifies molecular mechanisms governing PIEZO channel trafficking in C. elegans germline, showing dependence on RAB-11 and structural integrity, with implications for channelopathies.

The paper identifies PI4P's role in recruiting SNAP47 to facilitate SNARE-dependent AMPAR exocytosis during synaptic potentiation.

This study identifies Avl9 as a GTPase-activating protein for Arf1, showing its role in secretion and cell migration and suggesting other DENN domain proteins may also function as GAPs.

This study shows PHF1 interacts with SAR1 GTPase to assist in COPII assembly for PHT1 transporter ER exit in Arabidopsis.

This study shows CPAP stabilizes VPS4B protein and its localization to early endosomes, independent of its ESCRT-0 function, and reveals interactions critical for these processes.

The paper shows that clathrin turnover switches during endocytosis, affecting coat size and organization in yeast.

This study identifies sorcin as a factor linking annexin A11 to ESCRT-III assembly during plasma membrane repair, showing Ca2+-dependent scaffolding at sites of damage.

The paper determines the structure of cornichon receptors bound to an SLC transporter and shows how they couple membrane adaptation with cargo selection during ER export.

The paper identifies a new ESCRT-III like protein, Nbr9, in yeast through sequence analysis and shows it localizes to the plasma membrane but is not part of an alternative ESCRT-III complex.

The paper identifies VACs as specialized transport organelles delivering a preassembled apical cortex to the AMIS, enabling lumen initiation, and highlights PatJ's role in coordinating this process with cell-cell junctions.

This study identifies the proline-rich N-terminal domain of VAMP2 as the binding site for CD59, which promotes SNARE complex assembly, and shows that point mutations in CD59 do not impair this function.

This study identifies the role of AP-3 complex in regulating dense core vesicle (DCV) function, revealing its impact on exocytosis, positioning, and trans-Golgi budding, and identifies Dlk1 as a novel DCV cargo.

The paper shows that Erv14/cornichon receptor dynamics and bilayer thickness influence directional ER-Golgi traffic through a mechanism called HEIST.

This study shows that ALK endocytosis promotes glucose uptake in ALK-amplified neuroblastoma cells by delivering GLUT1 to mitochondria, independent of ERK and PI3K-AKT pathways.

This study compares PI(3,5)P2 biosensors and finds that SnxA is the most sensitive and unbiased tool for detecting this lipid.

The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.