Pancreatic function and diabetes

The paper uses single-cell multiome profiling to identify gene regulatory changes in pancreatic islets linked to diabetes risk factors like age, sex, and genetic variants.

This study investigates the interaction between neuronal calcium sensors and insulin, revealing Ca2+-dependent and -independent binding mechanisms and structural changes in NCS-1.

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

This study shows lipotoxicity increases beta-cell sEV release, which alter proteomic/lipidomic profiles and induce beta-cell dysfunction via the TGFβ/Smad3 pathway.

This study examines FSH receptor expression in human pancreatic islets and shows FSH enhances insulin secretion and cAMP levels, with associations between FSH and insulin indices in obese children.

This study uses single-cell RNA sequencing to analyze gene expression changes in human pancreatic islets under different glucose conditions over 24 hours, identifying genes and modules associated with time, glucose exposure, and their interaction.

The paper uses intravital imaging to show glucose-dependent cilia movement in live mouse pancreatic islets.

This study shows that β-hydroxybutyrate (βHB) increases insulin secretion and decreases glucagon secretion in human and mouse islets at physiological glucose concentrations.

The paper shows that CNOT7 deletion in mouse pancreatic β cells reduces insulin content and secretion by impairing proinsulin conversion, through reduced PRDX4 and increased CNOT8 binding to Prdx4 mRNA via MSI2.

The paper identifies miRNA signatures in FOXA2-deficient iPSC-derived pancreatic islets, showing altered miRNA-mRNA networks linked to diabetes and islet dysfunction.

This study shows PGE2 inhibits glucose-stimulated insulin secretion in β-cells via the EP2/4-Kv2.2 pathway by modulating Kv2.2 channels through PKA.

This study identifies 15 novel ductal cell populations in the mouse pancreas using scRNA-seq and investigates their roles in regeneration and exocrine pathogenesis.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

This study uses PET tracers to noninvasively monitor stem cell-derived islet graft volume and composition in mice, showing strong correlation with actual graft size and beta cell proportion.

PPCN, a thermoresponsive antioxidant polymer, supports islet viability and function in nonhuman primates when used for omentum transplantation.

This study shows sildenafil enhances insulin secretion in pancreatic β cells by increasing calcium influx, independent of L-type Ca2+ channels and PDE5.

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

This study shows that clonal human beta-cell spheroids enhance electrical activity and hormone secretion compared to monolayers, suggesting they are better models for studying beta-cell function.

The paper shows that G3BP1/2 form condensates with insulin mRNA in beta cells, which dissolve upon glucose stimulation, regulating insulin mRNA storage and translation.

The paper identifies driver genes for type 2 diabetes using causal network perturbation analysis and single-cell RNA sequencing in mouse models.

This study identifies harmine, 2-2c, and 5-IT as DYRK1A inhibitors that enhance both beta cell proliferation and differentiation, while others fail to induce differentiation.

This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.

This study shows that knocking out ALDH3B2 in human pancreatic duct cells converts them into beta-like cells that function and reduce blood glucose in mice.

This paper generates pancreatic aggregates from mouse stem cells with mesoderm and pancreatic progenitors, showing increased endocrine cell production compared to controls.

This study transplants human iPSC-derived pancreatic progenitors into Pdx1-deficient mice, extending their lifespan and demonstrating functional engraftment of human pancreatic cells.

The paper identifies the serotonin 1F receptor as a negative regulator of human beta cell survival during transplant and demonstrates a small molecule antagonist that improves glycemia in islet transplants.

The paper uses 3D imaging to reveal new heterogeneity in human pancreatic islets, showing 50% lack glucagon-producing cells.

The paper identifies chromosome 20p11.2 deletions as a cause of congenital hyperinsulinism by disrupting FOXA2 expression in pancreatic beta-cells.

The paper identifies IAPP as a marker for mature stem cell-derived β cells that maintain stable insulin production in vitro and in vivo, and finds that aconitine enhances IAPP expression.