Pancreatic function and diabetes

The paper investigates liver-pancreas interactions after beta-cell loss in zebrafish, identifying a role for the molybdenum cofactor in beta-cell regeneration and glucose metabolism.

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

This study identifies trace amines (TAs) as essential autocrine signaling factors for β-cell activity and insulin secretion, showing their modulation affects intracellular Ca2+ oscillations and insulin release.

The paper uses flexible electronics to study electrical maturation of human pancreatic islets over time, identifying key electrical states and their role in hormone secretion.

This study shows that RFX6 deletion in iPSCs impairs islet organoid development and survival through apoptosis and gene downregulation, without affecting PDX1+/NKX6.1+ progenitors.

This study investigates how human pancreatic islet cells respond to ER and cytokine stress and identifies T2D-associated genetic variants that modulate these responses.

This study compares SC-β cells with fetal and adult β cells using single-cell sequencing, finding they share a core β-cell identity but have unique transcriptional profiles with neural-biased gene networks.

This paper develops a β-cell-based platform for on-demand recombinant protein delivery by modifying the endogenous insulin processing pathway to produce and release therapeutic peptides like GLP-1 or glucagon.

This study shows IAPP-GFP localizes to mitochondria and forms filamentous aggregates in C. elegans, suggesting potential as a tool for screening IAPP-solubilizing compounds for T2D therapy.

This study uses adenoviral vectors to express CD8-TCR chains in pancreatic islets, enabling them to induce immune tolerance and protect against rejection without systemic immunosuppression.

The paper monitors miR-15a and miR-124 expression during adipose-derived mesenchymal stem cell differentiation into pancreatic beta-cells over 28 days, finding increased expression at day 28.

This paper uses a mechanistic model to evaluate how glucagon contributes to glucose regulation and how insulin dysfunction affects glucagon response in diabetes.

Applying sub-minute pressure at physiological levels enhances therapeutic insulin transport from macroencapsulated islets, enabling rapid glucose regulation in diabetic rodent models.

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

The paper identifies homozygous loss of function variants in ZNF808 as a cause of pancreatic agenesis in humans, showing its role in repressing transposable elements during pancreatic development.

This study shows that Robo2 in adult beta cells actively maintains islet architecture, as its deletion leads to loss of architecture without affecting beta cell identity or function.

This study profiles isomiRs in human pancreatic islets and beta cells, finding they represent a significant fraction of miRNAs and are associated with beta cell function.

This study develops a kinetic model of β-cell metabolism to identify key regulatory points in pyruvate cycling pathways involved in insulin secretion and NADPH production.

The paper studies a heterozygous missense variant in GLI2 in human iPSCs and finds it impairs endocrine pancreas development and predisposes to diabetes.

The paper proposes a model explaining how SERPINF1 suppresses angiogenesis in the human fetal pancreas acinar microenvironment using single-cell RNA-seq data.

This study functionally interrogates 20 T2D-associated genes using isogenic hESC-derived β-like cells, identifying variants and genes linked to insulin production and lipotoxicity sensitivity.

This study shows that the leptin receptor in mouse delta cells does not affect beta-cell function or glucose homeostasis.

This study identifies signaling pathways that enable the unlimited expansion of human pancreatic progenitors in defined conditions, leading to efficient and reproducible cell production for diabetes research and therapies.

This paper integrates multiple scRNA-seq datasets to create a mouse islet atlas, revealing new insights into β-cell states and differences across diabetes models.

This study shows that NRF2 dysregulation in mice impairs beta-cell proliferation and mass expansion during pregnancy, leading to gestational diabetes.

The paper shows that ECM and cell-cell adhesion coordinate to regulate islet aggregation, architecture, and functional maturation during development.

The paper uses real-time imaging to reveal dynamic processes in pancreatic lumen formation and remodeling, challenging existing models of polarity acquisition and network development.

The paper uses single-cell RNA-seq and live imaging to study NEUROG3 dynamics in human pancreatic endocrine progenitors, revealing differences in expression timing and proliferation patterns compared to mice.

The paper creates an integrated gene expression map of pancreatic islet cell types from healthy and diabetic donors, identifying marker genes and differential expression patterns.