Trypanosoma species research and implications

This study compares the infectivity of slender and stumpy bloodstream forms of Trypanosoma brucei in adult tsetse flies, finding stumpy forms more effective in infecting immune competent flies.

The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.

The paper investigates genetic differentiation between Glossina brevipalpis populations in two Mozambican National Parks, finding them to be isolated subpopulations with minimal gene flow.

The paper develops a new conditional gene expression system in Angomonas deanei using T7 RNA polymerase to enable genetic manipulations without interfering with endogenous transcription.

The paper investigates the genomic organization of tRNA genes in Trypanosoma cruzi, revealing synteny with Trypanosoma brucei and identifying chromatin insulator-like tRNA genes.

This study uses tagged tubulin to show that Trypanosoma brucei restricts microtubule assembly to the new flagellum during duplication but allows transient reassembly in mature flagella after cell division.

This study examines MCM protein expression and localization in Trypanosoma cruzi during metacyclogenesis and G1 arrest, revealing their role in cell cycle regulation and replication arrest.

This study identifies TcCARP3 as a regulator of cAMP signaling in Trypanosoma cruzi, essential for osmoregulation, host cell invasion, and vector colonization.

This paper shows that ATP-dependent phosphofructokinase (PFK) in Trypanosoma brucei functions gluconeogenically in vivo, challenging its traditional role in glycolysis.

The paper introduces a dual inducer system for RNAi complementation in Trypanosoma brucei, enabling independent and tunable regulation of gene expression to study kDNA replication.

Across nine Kenyan counties, Stomoxys flies fed on 15 vertebrate hosts, carried Anaplasma, Theileria/Babesia and Trypanosoma DNA, and transmitted T. vivax, T. evansi and Theileria mutans to mice.

This study shows that intermittent posaconazole treatment does not prevent cardiac and digestive tract pathologies in a chronic Chagas disease mouse model, even with high parasite burden reduction.

The paper identifies 28 novel glycosomal membrane proteins in trypanosomes, validates four new ones, and identifies PEX15 as a key protein essential for glycosome biogenesis and parasite survival.

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

This study shows statins do not reduce parasite burden in a mouse model of Trypanosoma cruzi infection, suggesting clinical trials for trypanocidal activity are unjustified.

The paper expands a protein-tagging toolkit for trypanosomes with over 100 vectors, enabling flexible localization and functional analysis of proteins using diverse fluorescent and biochemical tags.

This study uses high-resolution computational modeling to uncover new molecular interactions between T. cruzi gp82 and LAMP2, revealing cooperative motions critical for host-cell invasion.

This paper develops a Cas10-based lateral flow assay for detecting 7SL-sRNA in cattle with active trypanosomiasis, showing high sensitivity and specificity during chronic infection phases.

This study uses high-resolution scRNA-seq to uncover how genomic rearrangements during antigen switching in Trypanosoma brucei depend on repair mechanisms and homologous templates.

This study investigates the transport and metabolic roles of serine, threonine, and glycine in Trypanosoma cruzi, showing their importance in energy metabolism and stress response.

This study investigates the activity and essentiality of the putative Delta6-desaturase in Trypanosoma brucei, showing its role in producing specific polyunsaturated fatty acids and influencing lipid composition and morphology during life cycle transitions.

This study investigates the BBSome's role in Lotmaria passim, showing its importance for lipid raft integrity and infection efficiency, with functional differences compared to Leishmania mexicana.

This study introduces deep-sampling PCR to detect and quantify T. cruzi parasite load in chronically infected hosts, revealing large variations in parasite levels and enabling treatment monitoring.

The paper introduces a CRISPR/Cas9-based protein tagging system for Kinetoplastids that preserves endogenous regulatory elements and demonstrates its utility in studying gene regulation.

This study shows that reduced trTregs during T. cruzi infection correlates with tissue damage, and early IL-33 treatment increases trTregs and reduces damage.

This study identifies factors contributing to trypanocide failure in cattle with African animal trypanosomosis in Tanzania, finding drug quality, improper use, and resistance as key issues.

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.

This paper develops a reproducible murine model of T. brucei-induced myocarditis and cardiac dysfunction, showing immune-mediated cardiac damage and elevated NT-proBNP levels.

This study uses molecular and chromosomal analyses to reveal genetic diversity in the Sordida subcomplex, suggesting six putative species instead of three.

The paper identifies TelAP2 as an interacting partner of TelAP1 in the telomere complex of Trypanosoma brucei and shows that TelAP1 requires this interaction to associate with telomeric proteins.