Wnt/β-catenin signaling in development and cancer

The paper identifies FGF19 as a paracrine signal driving tumor growth in hepatoblastoma through Wnt-dependent mechanisms and biliary lineage activation.

The paper shows that three Wnt proteins control the polarity of somatic gonadal precursors in C. elegans, which is essential for mirror-symmetric gonad development.

This study shows UVB radiation reduces Dicer expression via activation of the WNT/β-catenin pathway and direct transcriptional repression.

The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.

This study identifies that Wnt ligand dissociation from Evi/Wntless occurs post-internalization in acidic endosomes in Drosophila wing epithelial cells.

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

This study shows SEL-5/AAK1 regulates cell migration and outgrowth in C. elegans without requiring kinase activity, and identifies Wnt signaling components involved in these processes.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

This study shows RNF43 and ZNRF3 differentially regulate endocytosis of specific Frizzled family members through their transmembrane domains, linking these differences to cancer mutation patterns.

This study identifies Deltex as a regulator of Wg signaling by modulating the gradient and degradation of Armadillo/β-catenin across species.

This study identifies a β-catenin peptide that inhibits Wnt signaling by blocking its nuclear translocation via interaction with IFT-A, showing potential for therapeutic applications in cancer.

This study identifies Tetraspanin12 as a co-receptor that directly binds Norrin to enhance its signaling through the Wnt/β-catenin pathway by capturing Norrin before it interacts with Fzd4.

This study identifies FBXW7 mutations as a mechanism of resistance to anti-Wnt/β-catenin therapies in RNF43-mutant/RSPO-fusion cancers and shows that these tumors are susceptible to multi-CDK inhibition.

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.

This study identifies LSD1 as a regulator of Wnt/β-catenin signaling by demethylating β-catenin to prevent its degradation, thereby influencing muscle stem cell self-renewal.

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

This study shows that vitamin D inhibits the Wnt/β-catenin pathway in colon cancer cells by activating SIRT1, which deacetylates and excludes β-catenin from the nucleus, reducing tumor growth.

This study shows that stabilizing β-catenin in mammary epithelium impairs branching morphogenesis and promotes epidermal differentiation over hair follicle fate.

This study identifies Erlotinib as a Wnt/β-catenin inhibitor effective in zebrafish and human cells, reducing leukemia-initiating cell self-renewal and disease progression.

The paper identifies a WNT7A-FZD5 signaling axis critical for human fallopian tube stem cell self-renewal using single-cell transcriptomics and organoid models.

The paper introduces a cell-specific targeting strategy called BRAID, validated using the WNT/{beta}-catenin system, showing it can induce signaling specifically on hepatocytes.

This study identifies CK2-dependent phosphorylation of Daam2 as a regulatory mechanism controlling oligodendrocyte development and myelin repair through Wnt signaling.

This study shows that PMA enhances Wnt signaling through macropinocytosis, with implications for cancer progression.

The paper shows that phosphorylation of a specific tyrosine in Vang/Vangl regulates its interaction with Pk and Dsh/Dvl, promoting the formation of the Vang/Vangl-Pk complex during PCP establishment.

The paper identifies the adult mouse intestinal stem cell niche as a multi-layered structure with distinct mesenchymal and smooth muscle cell populations that regulate ISC proliferation and differentiation.

This study shows that FZD2 mutations cause limb defects by disrupting both canonical and non-canonical Wnt signaling, using genetic mouse models to establish causality in Robinow Syndrome and omodysplasia.

The paper identifies novel interactions between the APC protein and Wnt-pathway nuclear transcription factors, suggesting APC may repress CTNNB1 through transcription factor binding.

This study investigates the evolutionary origin and conservation of tankyrases across species, showing their presence in choanoflagellates and conservation of core functions despite varying interaction partners.

This study identifies Kap-β2/Transportin as the nuclear transport receptor for β-catenin in Wnt signaling, showing its role in nuclear import and potential as a therapeutic target.

The paper shows that four Frizzled receptors in Nematostella vectensis have partially redundant roles in oral-aboral axis patterning via cWnt signaling, but not in endoderm specification.