Wnt/β-catenin signaling in development and cancer

The paper identifies Gas1 as a suppressor of hepatoblastoma tumorigenesis by showing its restoration inhibits tumor growth in mice and cell lines, and identifies a common set of B-Y-N regulated genes.

The paper shows Pdgfra+ fibroblasts reprogram during WNT-driven oncogenesis to promote a regenerative state in the epithelium, facilitating tumor formation.

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

The paper quantifies SYS-1 inheritance during asymmetric cell division in C. elegans and shows its regulation by centrosomal processing and Wnt signaling in both mother and daughter cells.

The paper identifies YM155 as a β-catenin condensate inhibitor using a NECO screening platform, showing its anti-proliferative effect on WNT-driven colorectal cancer organoids.

The paper identifies regulators of Dvl2 biomolecular condensates using image-based screens and phosphoproteomics, finding CK1δ/ε inhibition blocks condensate formation and modulates Wnt signaling.

This study shows that CMG2 is essential for intestinal stem cell renewal after injury, as its loss impairs stem cell regeneration and Wnt signaling in mice.

This study shows Frizzled2 is essential for cell survival under low-Wingless conditions, while Frizzled1 is not, revealing non-redundant roles in Drosophila wing development.

This study shows that tumor-associated ZNRF3 missense mutations do not exhibit dominant-negative activity and instead act as loss-of-function mutations at endogenous levels.

This study compares β-catenin sequences and function across nonbilaterian metazoans and Xenopus embryos, revealing conserved structural and functional properties of β-catenin complexes.

This study identifies DVL2 oligomer formation as essential for Wnt/β-catenin signaling, revealing two-step condensate formation through high- and low-affinity interaction sites.

The paper identifies distinct and overlapping roles of dact1 and dact2 in regulating noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial development.

The paper identifies a homozygous WNT11 variant causing laterality, heart, and renal defects in an infant and shows its loss-of-function in Xenopus embryos.

The paper shows that three Wnt proteins control the polarity of somatic gonadal precursors in C. elegans, which is essential for mirror-symmetric gonad development.

The paper investigates the evolution of the Wnt/β-catenin destruction complex in Nematostella vectensis, showing it functions similarly to bilaterians despite lacking conserved domains, suggesting an ancestral low-affinity binding mechanism.

This study shows UVB radiation reduces Dicer expression via activation of the WNT/β-catenin pathway and direct transcriptional repression.

This study investigates the effects of a DVL1 variant in a Drosophila model of Robinow Syndrome, showing disrupted morphogenesis and appendage formation with increased cell death and basement membrane changes.

This study identifies that Wnt ligand dissociation from Evi/Wntless occurs post-internalization in acidic endosomes in Drosophila wing epithelial cells.

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

This study shows SEL-5/AAK1 regulates cell migration and outgrowth in C. elegans without requiring kinase activity, and identifies Wnt signaling components involved in these processes.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

This study identifies Deltex as a regulator of Wg signaling by modulating the gradient and degradation of Armadillo/β-catenin across species.

This study shows that Semaphorin receptors antagonize Wnt signaling by promoting beta-catenin degradation, independent of primary cilia.

This study identifies olive polyphenols as tankyrase 1 inhibitors that suppress the Wnt/β-catenin pathway, reducing colon cancer cell viability and target gene expression.

This study identifies Tetraspanin12 as a co-receptor that directly binds Norrin to enhance its signaling through the Wnt/β-catenin pathway by capturing Norrin before it interacts with Fzd4.

The paper shows that Taiman promotes epithelial cell fitness by controlling the Wg gradient through Dally-like glypican, leading to cell competition in Drosophila wing discs.

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

This study shows that Wnt signaling in Drosophila wing imaginal discs reduces apoptosis caused by DNA damage by modulating the EGFR pathway through Rhomboid and DDR components.

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

This paper identifies FAXDC2 as a cholesterol biosynthesis enzyme that links Wnt/beta-catenin to RTK/MAPK signaling, showing its role in cancer progression and cellular differentiation.