Telomeres, Telomerase, and Senescence

The paper profiles Y1 cells treated with FGF-2, revealing epigenetic and transcriptomic changes consistent with oncogene-induced senescence.

This study identifies the PNUTS-PP1 axis as critical for endothelial aging and barrier function, showing that SEMA3B suppression mediates these effects.

This study shows TLK1/2 activity protects replication forks, contributes to chromatin silencing, and suppresses innate immune responses, with implications for immune evasion in chromosomally unstable cancers.

The paper shows that TRF1 deficiency protects aged cells from premature senescence by maintaining telomere cohesion and preventing DNA damage.

The paper investigates whether telomere length regulation by Rif1 is linked to telomeric origin firing, finding they are separable functions.

The paper examines telomere length and oxidative stress in a 3xTg-AD murine model, finding shorter telomeres in blood cells of older transgenic mice and increased oxidative stress with age, but no correlation between oxidative stress and telomere length.

This study uses single-molecule imaging to reveal a Recruitment-Retention model for telomere elongation, showing how hTERT and TPP1 regulate hTR dynamics and how mutations affect telomere homeostasis.

This study shows the human SKI complex prevents telomere instability by resolving DNA-RNA hybrids at telomeres during G2 phase.

The paper investigates telomere length and oxidative damage in children with autism, finding higher oxidative base lesions and variable TERRA expression between sexes.

The paper investigates the evolution and function of telomerase in Brassicaceae plants, finding that TER1 and TER2 are not functional telomerase RNAs and identifying a conserved telomerase RNA locus.

This study shows SMCHD1 is required for ATM-dependent DNA damage signaling and repair of uncapped telomeres, with its depletion reducing telomere fusions in TRF2-depleted cells.

The paper analyzes whole-genome sequencing data from cancer samples to identify genomic footprints of telomere maintenance mechanisms, finding specific telomere variant repeat patterns associated with ATRX/DAXX mutations.

The paper investigates how mutant POT1 alleles cause replication stress and telomere fragility, revealing a role for the nuclear pore complex in resolving these defects and telomere repositioning to the nuclear periphery.

The paper develops universal reference primers for qPCR-based telomere length measurement in any vertebrate species.

The paper identifies RADX as a telomere-binding protein that suppresses telomere fragility by counteracting RAD51 binding, alongside POT1.

This study investigates the effects of dasatinib plus quercetin on uterine fibrosis in aged mice, showing increased p53 expression and reduced miR34a levels.

This study shows that Ku proteins associate with human telomeres mainly through protein-protein interactions, not DNA binding.

The paper investigates t-loop dynamics during S phase, showing they unfold twice and persist throughout the phase.

The paper examines the relationship between oxidative stress, telomere length, and frailty in older adults, finding an association between telomere length and frailty but not between oxidative stress and these factors.

The paper shows that Tel1 activation by the MRX complex regulates telomere length but not the DNA damage response in S. cerevisiae, challenging existing models.

This study shows that loss of SATB1 in dopaminergic neurons leads to cellular senescence through p21 activation, suggesting a role for senescence in Parkinson's disease pathology.

The paper curates a database of senescence-associated genes and performs systems biology analyses to identify novel regulators and pathways of cellular senescence.

This study investigates telomere maintenance in fission yeast lacking telomerase, showing that TERRA RNA and shelterin component changes support recombination-based telomere maintenance.

This study identifies a new TIN2 isoform, TIN2M, and shows that all TIN2 isoforms enhance telomerase processivity beyond TPP1/POT1, suggesting TIN2 is a functional component of the TPP1/POT1 complex.

This study shows that reduced Ku's DNA end binding activity shortens telomeres by destabilizing Est1-telomere interactions, not by affecting TLC1 levels.

This study shows that C. elegans POT-1 proteins regulate telomeric foci in gametes across generations without affecting telomere length.

This paper shows that TERT, a telomerase subunit, regulates developmental processes in Dictyostelium discoideum through non-canonical mechanisms, affecting tissue size and aggregation.

This paper develops a DNA methylation biomarker, DNAmSen, to measure cellular senescence and shows its correlation with age and age-related diseases.

This study shows that inhibiting nucleotide synthesis induces replicative senescence in human mammary epithelial cells by blocking metabolic flux into nucleotide pathways.