Escherichia coli research studies

The paper provides 15 genomically characterized Shigella sonnei isolates representing diverse sub-clades, with complete genome sequences and public availability for research.

This paper investigates tolerance mechanisms in bacterial polysaccharide synthesis pathways, showing that sharing a common substrate allows UndP recycling and enhances survival when one pathway is disrupted.

The paper introduces a biochemical method to detect and analyze capsular polysaccharides in bacteria, improving upon traditional serotyping assays.

This study identifies persistent cross-species transmission systems between cattle and humans as a major driver of E. coli O157:H7 epidemiology in Alberta, with a shift toward more virulent stx2a-only strains.

The paper creates two databases, Escobase and AcR, containing E. coli genomes and acid resistance genes from cattle farm isolates to support comparative genomics and acid resistance research.

This study characterizes the genomic distribution and evolution of pks islands in E. coli strains associated with colorectal cancer, revealing phylogenetic patterns and horizontal gene transfer.

This study examines the prevalence of multidrug-resistant STEC in bovine subclinical mastitis milk and identifies their zoonotic risk through virulence gene analysis, antimicrobial resistance profiling, and phylogenetic relationships.

This study identifies genetic factors associated with invasiveness in Escherichia coli strains from IBD patients using whole genome sequencing and a modified invasion assay.

This study tracks E. coli dynamics in a human gut over 20 years, showing how strain properties and environmental factors influence diversity and persistence.

This study shows colibactin-induced DNA damage in bacteria occurs without cell contact, challenging previous assumptions about its delivery mechanism.

The paper investigates E. coli strains isolated from white-tailed deer during necropsy, analyzing their phylogenetic relationships and geographic distribution across Florida.

This paper develops exosome-based agents that bind and neutralize Shiga toxin type 1, showing protective effects in cell experiments.

This study shows that E. coli lacking a cell wall compensates by increasing extracellular matrix production, enhancing survival under stress.

This study identifies distinct E. coli transcriptional profiles in the guts of recurrent UTI sufferers using a novel pangenome hybrid selection method.

This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.

This study examines how LPS and Shiga toxin exposure affect gene expression in endothelial cells, finding synergistic effects at 24 hours.

This study identifies PAPP as a receptor for UPEC FimH binding, enabling bacterial invasion of luminal prostate cells in a murine organoid model.

This study shows that high-fat and high-carbohydrate diets exacerbate brain damage caused by Shiga toxin 2 in mice, with the combined diet causing the most severe neurological impairments.

The paper identifies EspH's interactions with Rab GTPases and phosphoinositides, showing their roles in immune signaling and membrane trafficking during EPEC infection.

This study identifies UPEC genes essential for growth and survival during the bladder infection cycle using TraDIS, revealing roles in nutrient utilization, cell envelope stress, and dispersal.

This study identifies key structural and glycosylation features of EtpA, an ETEC adhesin, and shows how antibodies target different epitopes to influence immune responses and pathogen-host interactions.

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

This study investigates the role of two type III secretion systems in Providencia alcalifaciens, showing their differential contributions to host interactions and pathogenicity.

This study identifies IpaH1.4 as a Shigella effector that degrades RNF213, preventing ubiquitylation of intracellular bacteria and evading host immunity.

This study shows engineered commensal E. coli can deliver anti-EHEC Tir nanobodies to block pathogen colonization and improve survival in a mouse model.

This paper investigates the expression of LEE genes and flagella in aEPEC 1711-4 during invasion and persistence in intestinal cells, finding increased expression of eae and escJ early on but no change during persistence.

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

This study shows that E. coli's serum resistance depends on the synergy between capsule and LPS, with LPS affecting capsule tethering and surface expression.

This study compares the pangenome and transcriptomic profiles of Shigella sonnei and Shigella flexneri to explain the epidemiological shift in their incidence.

This study develops a canine colonoid-derived monolayer model to study EHEC infection, showing decreased TEER and ZO-1 expression and increased TNF-α production.