Fungal Infections and Studies

This study uses single-cell RNA sequencing to show that checkpoint inhibitors like anti-CTLA-4 and anti-PD-1 shift the lung immune response in PCM toward a Th17-driven program involving neutrophils and macrophages, enhancing antifungal immunity.

This study shows caspofungin accumulates in Cryptococcus mitochondria via cardiolipin binding, reducing its effectiveness and linking to cardiotoxicity in human cells.

This paper identifies and characterizes the titanide morphotype of Cryptococcus neoformans, showing its distinct morphology, resistance to stress, and role in pathogenesis.

This study investigates the role of eIF3 subunits in stress adaptation and pathogenesis of C. neoformans, showing sensitivity to mitochondrial stress and differential drug responses in specific mutants.

This study shows that Rsp5 ubiquitination regulates trehalose biosynthesis in C. neoformans, enhancing thermotolerance and salt stress resistance.

The paper introduces a heat-ramp method to study regulated cell death in Cryptococcus neoformans, revealing a protracted cell death process in pathogenic yeast.

This study isolates and characterizes cryptococcal phagosomes from different host cells, revealing conserved fungal responses and suggesting host metabolism as a target for survival.

This study investigates the combined effects of mineral dust and Coniothyrium fuckelii on mouse lungs, revealing synergistic pathological changes and immune responses.

This paper analyzes whole-genome sequences of Cryptococcus deneoformans to find evidence of both a- and - sexual reproduction and recombination in natural populations.

This study identifies Cig1 as an immunogenic antigen in a heat-killed Cryptococcus neoformans vaccine model, showing its role in T cell recruitment and cytokine production.

The paper maps the transcriptional regulatory network of Cryptococcus neoformans by analyzing TF deletions and identifies functionally orthologous TF pairs across species.

This study shows that C. neoformans infection increases glycolytic activity in fetal liver-derived alveolar-like macrophages, which is HIF1-dependent.

This study identifies genetic determinants of CO2 tolerance in Cryptococcus neoformans through a genome-wide screen and shows it involves metabolic remodeling and stress response pathways.

The paper shows that reactive oxygen species (ROS) drive lethal inflammation in response to a C. neoformans chitosan-deficient mutant, highlighting ROS-dependent neutrophil-mediated immunopathology.

The paper analyzes the global genomic diversity of C. neoformans over three decades, identifying key genetic features, lineage divergence, and resistance mechanisms.

This study describes six new Cryptococcus species using genomic and phenotypic data, revealing ecological associations, chromosomal variation, and metabolic differences across the genus.

The paper presents the first telomere-to-telomere assemblies for two Paracoccidioides species, revealing chromosomal rearrangements and mitochondrial introgression.

This study compares laboratory and clinical assays for measuring cryptococcal polysaccharide, finding that structural variability among strains affects assay sensitivity and results.

This study shows that mutating the RIC8 gene in Cryptococcus neoformans enables unisexual reproduction involving meiotic recombination, suggesting it may be more common in nature than previously thought.

This study compares proteomic profiles of Cryptococcus neoformans clinical strains to identify differences between latent and lethal infections.

The paper identifies mixed plates in a Cryptococcus neoformans knockout collection and proposes an authentication method to distinguish between different KO libraries.

This study identifies multiple genetic routes to thermotolerance in Cryptococcus neoformans through experimental evolution under increasing temperatures.

This study shows that host LSD1 regulates lipid accumulation in macrophages during Cryptococcus neoformans infection by modulating lipophagy and WNT signaling, reducing fungal burden in mice.

The paper detects Histoplasma DNA in soil and bat tissue samples from Brazil, identifying environmental hotspots and multiple bat species as hosts.

The paper compares ddPCR and nested PCR for detecting Coccidioides DNA in soil samples near the U.S.-Mexico border, finding ddPCR more sensitive.

This study identifies Rpd3 as essential for temperature-mediated morphogenesis and virulence in Histoplasma by regulating gene expression and histone acetylation.

The paper investigates the early immune response to Coccidioides in mice, identifying PD-L1+ neutrophils and Spp1+ macrophages as key players in inflammation and fibrosis.

This study investigates how human microglia interact with Cryptococcus neoformans, showing limited phagocytic activity and ineffective killing of the fungus due to its ability to disrupt phagosome maturation.

This study uses solid-state NMR to reveal five structural forms of α-glucans in Cryptococcus cell walls, showing their role in scaffolding and interacting with chitin, capsule, and melanin.