Fungal Infections and Studies

This study shows that STRIPAK complex defects in Cryptococcus neoformans lead to pseudosexual reproduction, affecting genome stability and inheritance.

This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.

This study identifies Eng2 as a conserved antigen in dimorphic fungi that elicits protective immunity and memory T cell responses in mice and humans.

This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.

This study uses mass spectrometry to analyze proteome changes in three organs during Cryptococcus neoformans infection, identifying new immune modulatory mechanisms and antifungal targets.

The paper shows that rapid gain and loss of chromosome seven in Histoplasma affects morphology, virulence, and environmental adaptation.

This study investigates the role of Vac8 in Cryptococcus neoformans, showing its impact on vacuolar morphology, stress responses, and virulence.

This study uses timelapse imaging to analyze Cryptococcus neoformans infection dynamics in Galleria mellonella, revealing two distinct mortality phases and deterministic infection progression.

This study shows that peroxisomes in Cryptococcus neoformans regulate virulence and cell density sensing through metabolic pathways and mitochondrial retrograde signaling.

The paper identifies a large expansion of knottin genes in Histoplasma and shows their role in virulence and host cell lysis during macrophage infection.

This study shows that Rtf1's HMD domain promotes H2B monoubiquitination and regulates morphogenesis and virulence in Cryptococcus neoformans, independent of Paf1C.

This study adapts the tetracycline-repressible system to regulate essential gene expression in Cryptococcus neoformans, demonstrating its effectiveness in depleting HSP90 and inhibiting fungal growth.

The paper detects airborne Coccidioides spores using UAS-mounted samplers in California, finding Coccidioides DNA in 4.9% of air samples at 8 m height.

This study creates a transcriptomic atlas of Coccidioides development, identifying spherule-enriched transcripts and RYP1-regulated genes critical for virulence.

The paper examines the relationship between soil microbial communities and Coccidioides immitis presence in rodent burrows and surface soils, finding higher microbial diversity in Coccidioides-positive samples.

This study characterizes melanin in Lomentospora prolificans, revealing multiple melanin types and suggesting a new type synthesized alongside DHN-, DOPA-, and pyomelanin.

This study shows that growing Cryptococcus neoformans in unbuffered YNB media improves gene deletion efficiency using short homology arms.

This study characterizes two clinical Sarocladium spinificis strains that inhibit Coccidioides posadasii growth, revealing their genomic features and potential antifungal properties.

This study shows that polyphosphate mobilization is critical for Cryptococcus neoformans virulence in a mouse model, affecting cell surface structure, immune response, and mitochondrial function.

The paper investigates the distribution of Scedosporium and Lomentospora fungi in Taiwan, finding that human activity, not environmental factors, is the main driver.

This study characterizes transcriptomic changes in Coccidioides posadasii across different morphologies using RiboMarker-enhanced RNA sequencing, revealing small RNA and fragment expression patterns associated with life stage transitions.

This study tests star-shaped glatiramer acetate in a murine C-IRIS model, finding it reduces Th1 cells and neurodegeneration while improving lung function and survival.

This study uses long-read sequencing to analyze the genomes of three neurotropic dematiaceous fungi, revealing insights into their metabolism, stress adaptation, and virulence mechanisms.

This study optimizes in vitro spherulation in Coccidioides by adjusting culture conditions, media composition, and arthroconidium preparation to enhance spherule growth and endospore release.

This study uses single-cell RNA sequencing and spatial transcriptomics to analyze lung immune responses during lethal Coccidioides infection, identifying macrophages and neutrophils involved in fibrosis and immune dysregulation.

This paper investigates how salinity and polysaccharide rafts affect the buoyancy and persistence of Cryptococcus cells in water, with implications for their transport and pathogenic potential.

The paper reports the whole-genome sequencing of Hyphopichia burtonii isolated from zebra dove droppings in Thailand, identifying antifungal resistance and potential public health risks.

This paper investigates the role of the STRIPAK complex in Cryptococcus neoformans, showing it regulates genome stability, sexual development, and virulence through functional characterization of its subunits.

The paper characterizes the phenotypic landscape of Cryptococcus neoformans by analyzing gene deletions and their fitness under various conditions, revealing novel biological insights.