Toxoplasma gondii Research Studies

This study enables the study of Chromera velia's biology by developing cell transformation and expansion microscopy techniques, revealing insights into its subcellular organization.

This study examines metabolic changes in multiple tissues during toxoplasmosis, finding that immune responses, not parasite burden, drive metabolic perturbations in chronic infection.

This study identifies TgWIP interactions with Nck1/Grb2 and the WAVE complex to reveal how Toxoplasma manipulates host cell actin dynamics and motility.

This study investigates the role of equilibrative nucleoside transporters in Toxoplasma gondii, showing that TgENT1 is critical for bradyzoite differentiation and identifying it as a therapeutic target.

This study confirms that Toxoplasma gondii induces a transient increase in host cell plasma membrane conductance during invasion, suggesting a perforation mechanism for rhoptry protein delivery.

The paper identifies a transient membrane conductance increase in host cells induced by Toxoplasma gondii, which precedes invasion and is termed the invasion pore.

This paper shows that GCN5a loss in Toxoplasma gondii promotes latency by causing telomere dysfunction and altering gene expression during differentiation.

This study maps the Toxoplasma gondii interactome using crosslinking mass spectrometry and machine learning, identifying 405 PPIs with high confidence and validating their biological relevance.

This study investigates the formation of subpellicular microtubules in Toxoplasma gondii using expansion microscopy and genetic analysis, revealing their co-dependent assembly with the inner membrane skeleton.

This study shows that co-culturing feline intestinal organoids with human fibroblasts improves their growth, survival, and size, offering a better method for research.

This study identifies IMT1 as a protein linking the inner membrane complex and subpellicular microtubules in Toxoplasma gondii, revealing its role in regulating cytoskeletal interactions.

This study shows that RAD51 is essential for Toxoplasma gondii tachyzoite replication and that its inhibition leads to replication stress and bradyzoite differentiation.

This study finds that fallow deer approaching humans are more likely to be seropositive for Toxoplasma gondii, suggesting a potential link between risk-taking behavior and infection.

This study introduces ToxoFUCCI sensors to analyze the complex cell cycle of Toxoplasma gondii, revealing an unusual composite cell cycle phase with overlapping stages.

This study shows that Toxoplasma gondii infection of neurons reduces EV production and alters their content, leading to changes in astrocyte phenotype and GLT-1 loss.

This study quantifies amylopectin granule dynamics in Toxoplasma gondii tissue cysts during chronic infection, revealing a temporal cycle linked to bradyzoite replication and mitochondrial activity.

The paper compares neuronal transcriptional responses to Toxoplasma gondii and RNA viruses, identifying conserved and pathogen-specific immune responses in neurons.

This study shows that latent Toxoplasma gondii infection reduces visceral nociception in mice via peripheral opioid receptor signaling, suggesting a potential negative link with abdominal pain in humans.

The paper identifies GRA12 as a critical secreted virulence factor in Toxoplasma gondii that functions across different parasite strains and mouse species.

This study investigates the role of the ingestion pathway in Toxoplasma gondii nutrient acquisition by analyzing mutants lacking key pathway components, revealing reliance on biosynthetic pathways and highlighting the pathway's role in nutrient scarcity.

This study identifies TgGSK as an essential kinase in Toxoplasma gondii that regulates centrosome division and endodyogeny, with roles in RNA processing and interactions with GCN5b.

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

This study investigates how chronic Toxoplasma gondii infection affects neurodegenerative disease progression in a rat model of hereditary spastic paraplegia, finding exacerbated symptoms in infected rats.

This study identifies TgPROP1 as essential for autophagy and chronic infection of Toxoplasma gondii bradyzoites, while TgPROP2 is not involved in bradyzoite autophagy.

This study evaluates the anti-Toxoplasma gondii activity of extracts from eight plants, identifies nine compounds from Elaeis guineensis leaves, and suggests a synergistic effect among them.

This study compares motility and motility-dependent processes in Toxoplasma gondii tachyzoites and bradyzoites, revealing similarities and differences in their movement and invasion capabilities.

The paper identifies 44 compounds with >50% inhibitory effects against Toxoplasma gondii bradyzoites using a high-throughput screen and characterizes one compound's activity.

The paper identifies iron-mediated post-transcriptional regulation in Toxoplasma gondii by showing that a stem-loop structure in the 3' UTR of a gene stabilizes its transcript and protein under low iron conditions.

The paper identifies TgGloL, an atypical apicoplast protein in Toxoplasma gondii, essential for parasite growth and organelle homeostasis.

This study identifies a novel genotype of Toxoplasma gondii from wild animals in Gabon, Africa, which is genetically distinct from domestic and other global populations.