3D Printing in Biomedical Research

This paper introduces a 4D bioprinting platform that enables programmable shape-morphing of tissues through viscoelastic hydrogels, enhancing structural and functional properties of iPSC-derived heart tissues.

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

This paper introduces HITS-Bio, a high-throughput spheroid bioprinting system that enables scalable tissue fabrication with high cell viability and speed.

This study develops clickable PEGNB microbeads that enable suspension bioprinting and microvascular self-assembly for engineering hierarchical vasculature.

This study introduces a 3D tumor model called ToP for generating predictive cancer models and screening therapeutics for glioblastoma and pancreatic adenocarcinoma.

This paper develops programmable bioinks using aptamers to control VEGF release and modulate microvascular network formation in 3D-bioprinted constructs, showing improved network properties with low-resolution designs.

This study evaluates developmental neurotoxicity using dynamic cerebral organoid cultures in a pillar/perfusion plate, showing methylmercury induces changes in morphology and gene expression under dynamic conditions but not static ones.

This paper develops a method to engineer non-embedded liver sinusoids by guiding endothelial cell self-organization using micropatterns, resulting in lumen formation without supporting cells or scaffolds.

This paper develops a scalable in vitro liver model with microvascular components to study disease and drug responses, showing it can model steatosis and fibrosis.

This paper develops a tumor-on-a-chip model to study ovarian cancer drug resistance by mimicking tumor-stroma interactions and compartmentalized microenvironment.

This paper develops a biophysical model to predict diffusion in 3D cell aggregates by addressing boundary conditions, validated through simulations and experiments with liver spheroids and glucose.

This paper introduces a high-throughput microphysiological system that demonstrates enteric innervation enhances duodenal epithelial barrier function and reduces EGF expression.

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

This paper demonstrates the use of PEGDMA as a composite bioink to enhance mechanical properties in SLA bioprinting, supporting cell proliferation in vitro.

This paper introduces Organ Chips with integrated sensors for continuous metabolic monitoring under controlled oxygen levels, demonstrating functionality in human Gut and Liver Chip cultures.

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

This paper develops a human heart-on-a-chip model using iPSC-derived cardiomyocytes, fibroblasts, and vascular endothelial cells, showing improved cardiac function and responses similar to in vivo hearts.

This paper introduces methods to print biomimetic vascular networks into tissue matrices, demonstrating their functionality in cardiac tissues.

This paper introduces a polycarbonate gut microbiome-distal tumor chip platform that supports anaerobic bacteria and high-resolution microscopy for studying cancer-promoting mechanisms.

This paper introduces a voxelated bioprinting method to create double-network hydrogel droplets with precise 3D assembly and mechanical properties.

The paper introduces a microphysiological platform for culturing transwell-based lung tissues, enabling high-resolution live-imaging of airway infections and tissue responses.

This paper introduces CLADDING, a bioprinting method using a self-healing transparent support bath to enable printing of low-viscosity protein-based bioinks with high cell viability.

The paper develops engineered microvascular networks with a KLF2 reporter to study flow effects on vascular structure and function, finding increased KLF2 expression correlates with larger vessel diameters and improved barrier function.

This paper introduces Optical Fiber-Assisted Printing (OFAP), a new 3D printing technique that enables precise patterning and freeform fabrication using photopolymer resins.

This paper develops a hiPSC-derived intestine-on-chip system that mimics the human small intestine's epithelial, mesenchymal, and neural composition and function.

This paper develops bioengineered human colon organoids that mimic in vivo complexity and function, enabling long-term study of gut physiology and disease.

The paper presents a platform for minimal-invasive 3D laser printing of microimplants in vivo using synthetic polymer inks, demonstrating biological responses in teleost fish and fruit fly embryos.

This paper develops a nanoporous PEGDA ink for high-resolution 3D printing of scaffolds in organ-on-a-chip systems, showing improved cell adhesion and viability.

This study introduces a fluid-phase 3D printing method to pattern hydrogel properties, enhancing cell growth and behavior in vitro by adjusting stiffness and adding bioactive molecules.

The paper introduces a thin plate spline method to model tissue boundaries in organ-on-chip models and quantify tumor cell invasion.