Neuroinflammation and Neurodegeneration Mechanisms

Dense CRISPR Mapping of the WAVE Complex Identifies Pharmacological Modulators of AD-Linked Myeloid Migration

The paper uses CRISPR mapping to identify pharmacological targets for modulating microglial migration linked to Alzheimer's disease.

Nuclear Cx43 restrains microglial neurotoxicity during brain development

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

Prolonged systemic inflammation worsens impairments to astrocyte Ca2+ and functional hyperemia in Alzheimer's disease

This study investigates how prolonged systemic inflammation exacerbates astrocyte dysfunction and neurovascular coupling impairments in Alzheimer's disease.

Diverse origins and transcriptional profiles of macrophages in a spinal lesion in zebrafish

The paper identifies heterogeneous and dynamic gene expression in macrophage subpopulations during zebrafish spinal cord regeneration.

STING restrains calcium-dependent microglial phagocytosis and protects against neuronal loss and cognitive impairment during epileptogenesis

This study shows that STING inhibits microglial phagocytosis and protects neurons during epileptogenesis by regulating calcium signaling through the STING-STIM1-SOCE axis.

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

Microglia-Specific Molecular Magnetic Resonance Imaging Probe Enables Noninvasive Separation of Parkinsonian Mice from Controls

A microglia-targeted MRI probe distinguishes Parkinsonian mice from controls by generating disease-specific contrast through radiomics analysis.

Systemic infections alter cortical transcriptional signatures in Alzheimer's disease

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice

This study compares the effects of TREM2 R47H mutation and TREM2 deficiency in aged AppNL-F mice, finding that the mutation causes mild, functionally distinct microglial changes compared to a null effect.

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia

This study shows cortistatin deficiency worsens brain ischemia by increasing neuroinflammation and vascular dysfunction, while cortistatin administration improves outcomes.

APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Model of Amyloidosis

This study shows that disrupting the brain-spleen axis accelerates disease progression in amyloidosis by impairing monocyte-microglia communication.

High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimers Disease

This study uses HT-CETSA to identify small molecule modulators of ILT3, showing functional activity in human iPSC-derived microglia for Alzheimer's disease.

GPCR-mediated regulation of glial TNF production

This study investigates how GPCR signaling pathways modulate TNF production in glial cells, finding that Gs and Gq pathways reduce TNF while Gi increases it.

Context-dependent effects of microglial MyD88 removal on voluntary ethanol consumption in mice

This study examines the role of microglial MyD88 signaling in voluntary ethanol consumption in mice, finding minimal effects on drinking but potential developmental context influences.

CSF1R-Mediated Microglial Engagement Is Required for Stress-Induced MMP-2/9 Activity

This study shows that microglial CSF1R signaling is required for stress-induced MMP-2/9 activity in the nucleus accumbens core.

Disrupted maternal care alters neural-microglia interactions in the primate paralaminar (PL) nucleus of the amygdala.

This study shows that maternal separation disrupts synaptic pruning and microglia-synapse interactions in the primate paralaminar nucleus, leading to reduced mature neurons by adolescence.

Spatial Transcriptomics reveals a T cell-mediated microglial activation axis of neurodegeneration following immune checkpoint inhibition

This study uses spatial transcriptomics to show that immune checkpoint inhibitors activate microglia via T cell interactions, leading to neuroinflammation and synaptic dysfunction in the brain.

Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities.

The paper compares senescent and reactive astrocytes, finding distinct gene expression profiles and functional capacities, with senescent astrocytes supporting neurite outgrowth while reactive astrocytes do not.

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models

This paper identifies S9, a small molecule TREM2 agonist that reprograms microglia and protects synapses in Alzheimer's models, showing therapeutic potential.

Phosphoinositide turnover through PLCγ regulates Draper-dependent engulfment in glia

This study shows that PLCγ-dependent phosphoinositide turnover regulates Draper-mediated glial engulfment in Drosophila, linking PLCG2 to neurodegenerative disease risk.

Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis

This study identifies KAT7 as an epigenetic regulator that drives microglial mitochondrial immunity and Alzheimer's disease pathogenesis by enhancing mtDNA-driven inflammation and amyloid-β burden.

Temporal multi-omic profiling of immune, gut, and microbiome responses to ischemic stroke reveals convergence of host and microbial perturbations one week after brain injury

This paper uses multi-omic profiling in a mouse stroke model to show that host and microbial changes converge around day 7 post-injury.

C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair

This study identifies the C9orf72/SMCR8 complex as essential for microglial lysosomal repair and homeostasis, revealing its role in preventing neuroinflammation through RAB8A-ESCRT pathways.

A post-inflammatory C3-high astrocyte state persists after inflammatory stimulus withdrawal and is attenuated by JAK inhibition

The paper shows that inflammatory stimulation leads to a persistent C3-high astrocyte state after stimulus removal, which is reduced by JAK inhibition.

Specific deletion of interleukin-1 beta in microglia improves acute outcome and modulates neurogenesis after ischemic stroke

This study shows that deleting microglial IL-1β improves acute stroke outcomes and modulates neurogenesis, with effects more pronounced in females.

Neuronal UBE3A loss engages a TNF-driven neuron-to-microglia axis that promotes synapse remodeling

This study shows that neuronal UBE3A loss triggers a TNF-driven neuron-to-microglia signaling axis that promotes synapse remodeling and microglial inflammation.

Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala

This study identifies astrocyte reactivity in the central amygdala due to ethanol dependence through multi-omics analysis in mice, revealing adaptive and maladaptive changes in neuroimmune and cytoskeletal pathways.

NOD2 activation reprograms infiltrating inflammatory monocytes in the Zika virus infected CNS to maintain neural correlates of learning and memory

This study shows that NOD2 activation with MDP during ZIKV infection shifts monocytes to an anti-inflammatory state, preserving synapses and cognitive function in the hippocampus.