Adipose Tissue and Metabolism

This study tests if baclofen reduces body weight in rats by stimulating brown fat metabolism via the sympathetic nervous system, but finds propranolol does not block this effect.

This study shows that MitoKATP channels regulate brown adipocyte differentiation and metabolism, impacting thermogenesis through effects on oxygen consumption and cellular respiration.

The paper identifies fetal liver-derived macrophages in embryonic BAT that interact with developing nerves, influencing tissue morphology and function.

This study uses non-contrast microCT to analyze obese adipose tissue in mice exposed to cold, revealing sex-specific thermogenic adipose formation and metabolic changes.

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

CCT-217, an siRNA therapy targeting CB1R and ZFP423, reduces body weight and visceral fat while preserving lean mass and improving metabolic health in obese mice.

This study shows that Nipsnap1 overexpression in mice increases energy expenditure and lipid beta-oxidation, linking peroxisomal and mitochondrial beta-oxidation pathways to sustain thermogenic fat activation.

This study identifies a seasonal regulation of satiety-related genes and proteins in brown bear adipose tissue during hibernation, suggesting a local mechanism for energy management and satiety.

This study shows that PFKFB3 in adipose tissue affects glucose metabolism and metabolic health, particularly with aging and high-fat diets.

The paper shows that browning of white adipose tissue maintains UCP1-dependent thermogenesis despite loss of lipases in brown adipocytes.

This paper establishes protocols for creating immortalized brown and white preadipocyte cell lines from young and aged mice to enable long-term studies of adipogenesis and adipocyte biology.

The paper shows that ID1 and ID3 upregulation is crucial for thermogenic response in human adipocytes under adrenergic stimulation.

This study identifies HuR-dependent regulation of RyR2 expression as critical for calcium-mediated thermogenesis in brown adipocytes, showing that HuR stabilizes RyR2 mRNA to enhance calcium cycling and heat production.

This study shows TRPV4 inhibition increases lipid accumulation in adipocytes by altering mitochondrial parameters and lipid-droplet formation.

The paper shows that human adipocytes from different anatomical depots have distinct gene expression programs, suggesting depot-specific developmental programming rather than just environmental adaptation.

This study identifies AQP1 as a BAT silencing factor and shows that its knockout activates NST under cold conditions, protecting against diet-induced obesity and metabolic dysfunction.

This study shows that reversing Pdgfrβ signaling in aged and obese mice restores beige adipocyte formation and improves metabolism by enhancing ILC2 activity.

This study investigates whether sympathetic innervation of brown adipose tissue mediates oxytocin-induced weight loss in diet-induced obese rats, finding it is not required.

This study shows that estrogen protects female mice from adipose progenitor cell exhaustion during diet-induced obesity, but this protection is lost after ovariectomy.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

This study shows that chronic beta3-AR stimulation improves metabolic function in aged mice by enhancing thermogenesis in brown adipose tissue and lipid turnover in white adipose tissue.

The paper identifies linoleic acid diols that inversely associate with BMI and activate adipocyte calcium fluxes using a novel tool called ScreenDMT.

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

This study investigates the role of the mitochondrial pyruvate carrier (MPC) in adipose glucose partitioning, finding sex-dependent effects on triglyceride synthesis and metabolic adaptation in mice.

This study shows that sympathetic innervation of interscapular brown adipose tissue is not required for oxytocin-induced weight loss and thermogenesis in diet-induced obese mice.

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.