Barrier Structure and Function Studies

The paper shows that capillary injury and regression lead to sustained vasoconstriction in upstream vessels, reducing blood flow in both injured and uninjured regions of the microvascular network.

This study develops and validates a mouse model of sepsis-induced cognitive dysfunction, identifying molecular and functional changes in the cerebral microvasculature and their association with cognitive impairment.

This study investigates the brain distribution of remoxipride, showing that brain metabolism, not just BBB efflux, affects Kp,uu,BBB values less than 1.

This study identifies key residues in claudin-4 that enable polymerization when supplemented with claudin-3 residues, enhancing tight junction formation and barrier function.

This study shows that SCF and G-CSF enhance monocyte adhesion to brain endothelial cells via CCR5, facilitating their entry into the adult brain to replenish perivascular macrophages.

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

The paper identifies gene expression changes in the hippocampus and cerebral cortex of diabetic mice with minor cognitive deficits, highlighting CLDN5 downregulation and IRF7 upregulation as potential contributors to early cognitive decline.

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

This study identifies age-related changes in cerebrovascular structure and function in the mouse brain, including reduced vascular length and increased tortuosity in specific regions.

This study compares the neuroinvasion capabilities of Usutu and West Nile viruses across an in vitro blood-brain barrier model, finding USUV replicates to lower titres but induces similar immune responses.

This study shows that monocytic Occludin promotes monocyte transmigration into the CNS and that targeting it with peptides can block HIV neuroinvasion.

This study shows neurons enhance blood-brain barrier function by increasing claudin-5 and VE-cadherin via GDNF secretion and develops a triple co-culture model to predict BBB permeability.

This study uses patient-derived neurovascular units to show that TSC2 mutations impair BBB function, which can be rescued by wild-type astrocytes or rapamycin treatment.

This study shows SARS-CoV-2 causes blood-brain barrier and choroid plexus barrier damage and vascular inflammation in mice, contributing to neurological complications.

This study identifies NTE/SWS's role in maintaining BBB integrity and links its dysfunction to lysosomal storage diseases, inflammation, and fatty acid metabolism abnormalities.

This study shows IL-1β disrupts BBB development by inhibiting endothelial Wnt/β-catenin signaling in zebrafish.

This paper develops a patient-derived BBB model to screen copper bis(thiosemicarbazone) complexes for Alzheimer's disease treatment, identifying CuII(dtsm) as a promising candidate with improved BBB permeability and anti-inflammatory effects.

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

This paper introduces TREKING, a method combining kinase inhibitor screens and machine learning to generate time-resolved phosphosignaling networks, revealing MAPK pathway dynamics in endothelial barrier regulation.

This study compares iPSC-derived pericytes to primary human brain vascular pericytes, showing they express pericyte markers and respond to growth factors and vasoactive mediators, though with gene expression differences.

The paper synthesizes and evaluates 17-oxime ethers of oxidized ecdysteroids, finding they modulate oxidative stress in BBB cells with dose-dependent protective or damaging effects.

This study shows that tight junction membrane proteins regulate the mechanical resistance of apical junctions in epithelial cells by maintaining ZO-1 molecule organization.

This study shows engineered Wnt7a ligands improve blood brain barrier and neurobehavioral deficits in a SARS-CoV-2 infected mouse model.

This study shows that PALS1 regulates tight junction protein localization at bicellular junctions in renal epithelial cells, preventing increased paracellular permeability.

The paper investigates age and sex differences in BBB function using MRI in 186 participants, finding more pronounced decline in males starting in the early 60s, particularly in parietal and temporal regions.

This study shows blood flow promotes brain pericyte proliferation via Piezo1 in zebrafish, highlighting a new role for hemodynamics in vascular development.

This study investigates the in vitro and in vivo transport of three (poly)phenol metabolites across the blood-brain barrier and their effects on BBB properties.

The paper shows pericytes constrict during ischemia, remain constricted post-reperfusion, and contribute to no-reflow, with some surviving and upregulating transcripts, suggesting they are therapeutic targets.

This study shows that endothelial EGFR signaling is crucial for functional hyperemia, as its deletion impairs cerebral blood flow responses to neuronal activity.