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This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.

The paper describes an automated method for sequential chromogenic IHC double staining using DAB and HRP Magenta with a new acid block to reduce cross-reactivity.

This study shows that KMO inhibition protects against renal ischemia-reperfusion injury in mice by reducing renal damage and inflammation.

This study shows EGCG treatment improves facial dysmorphology in DS mouse models and humans but warns against non-prescribed use due to variable outcomes.

This paper introduces a method for quantitatively assessing Duchenne Muscular Dystrophy severity using computer-aided analysis of histopathological images.

The paper uses proteomic analysis to study protein dynamics in mouse cardiac remodeling, identifying adaptive and maladaptive changes and their underlying mechanisms.

This study evaluates the yield of universal testing for DNA mismatch repair protein deficiency in colorectal carcinoma, identifying MMR protein deficiency rates and age-related patterns.

This study develops a novel murine model to investigate how postnatal hip instability affects acetabular dysplasia and impingement, finding that severe instability leads to dislocation and morphometric changes.

This study shows that dim light at night increases the infectiousness of house sparrows to West Nile virus, potentially raising outbreak risk by 41%.

This study shows that exosomes from DMD fibroblasts promote fibrosis by transferring miR-199a-5p, which reduces caveolin-1 and activates fibroblast-to-myofibroblast conversion.

This study describes dental erosion in a Late Holocene child from Brazil, suggesting gastroesophageal reflux as a possible cause of death.

The paper examines elastin remodeling in Amniotic Band Syndrome (ABS) constriction rings, finding localized elastin fragmentation and absence in papillary dermis, suggesting differential elastin expression during fetal healing.

This study identifies multiple QTL associated with powdery mildew resistance in strawberry, including stable and transient loci, and suggests their use in marker-assisted breeding.

This study evaluates a laboratory demand optimization intervention in primary care, finding reduced test request volume and variability, with notable differences between rural and urban practices.

This study identifies DNM3OS as a key regulator of fibroblast activation via miRNAs, offering a therapeutic target for fibrotic diseases like IPF.

This study develops a murine model of diabetic tendinopathy and shows that restoring normal metabolic function does not reverse tendon impairments caused by obesity/T2DM.

This study shows UV-induced keratin 1 proteolysis causes skin damage, identified through mouse models and protease inhibition experiments.

The paper analyzes dental pathology and wear in medieval remains to infer diet and behavior, finding high caries and calculus rates suggesting continued consumption of cariogenic foods.

This study shows that endothelial cell-specific MCPIP deletion leads to endothelial dysfunction and impaired post-ischemic angiogenesis.

This paper introduces a label-free method using SLIM to detect breast cancer with high sensitivity and specificity by analyzing tissue nanostructure.