Discover, rate, and discuss biology preprints.

This paper presents a method to image unfixed, never frozen human brain tissue using cryo-ET with xenon plasma FIB milling, revealing native ultrastructures like myelin and autophagy components.

This paper develops automated tumor immunophenotyping pipelines to predict clinical benefit from anti-PD-L1 therapy in NSCLC and TNBC patients.

This paper generates a partially humanized mouse model of PKU with the c.1066-11G>A PAH variant, showing splicing defects, metabolic imbalances, and neurological phenotypes.

ComPRePS improves renal pathology analysis by automating WSI processing and AI-assisted interpretation, enhancing precision and interobserver agreement in key lesion assessments.

This study finds the serum proteome is remarkably similar between type 2 diabetics and controls, with major differences being glycations of abundant proteins and associations between BMI and a ternary complex.

This study uses oxidation-reduction imaging of myoglobin to show two-phase oxidation in reperfused myocardium and links it to MI size estimation.

This study identifies tensed fibronectin fibers in Salmonella-induced intestinal edema in mice, highlighting their potential role in maintaining tissue integrity during inflammation.

This study examines how SARS-CoV-2 variants infect nasal and olfactory tissues, showing differences in tropism, immune response, and regeneration across age groups.

This study reports on an 8-year monitoring effort of a biological control program using the rust fungus Puccinia punctiformis to reduce Canada thistle stem densities in Colorado, finding declines linked to environmental factors and inoculum deployment.

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

This study identifies DEGs and their roles in phenamacril resistance in Fusarium asiaticum through comparative transcriptome analysis of sensitive and resistant strains.

This paper introduces a novel mouse model for temporomandibular joint osteoarthritis by combining synovectomy and burn injury to simulate disease progression.

This study identifies and evaluates entomopathogenic fungi effective against spittlebug nymphs but not adults, with one strain showing high mortality potential.

This study investigates the pathogenic effects of the p.R130S prestin variant in DFNB61 hearing loss, showing it causes progressive outer hair cell loss and reduced motor kinetics.

The paper functionally characterizes deafness-associated pendrin and prestin variants using in vitro assays to assess their pathogenic impacts.

This study shows that reducing SAA with antisense oligonucleotides limits AAA progression in obese mice treated with AngII.

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

This study uses multiplexed imaging to analyze immune and stromal cell changes in abdominal aortic aneurysms (AAAs) based on C-reactive protein (CRP) levels, revealing distinct immune cell distributions and macrophage phenotypes associated with CRP deposition.

This paper shows that TAK-779, a CCR5/CXCR3 antagonist, prevents diffuse alveolar damage in a murine model of SARS-CoV-2-induced ARDS by reducing mononuclear infiltration and cytokine levels.

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.