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The paper quantifies age-related changes in regulatory and functional proteins in baboon adrenal zonae, finding decreased ZF function and less marked ZR function with age.

The paper highlights how reliance on self-reported and estimated food data in nutrition research introduces significant bias, and argues for the use of biomarkers to improve accuracy.

Short-term isoleucine deprivation in Drosophila extends lifespan and improves toxin resistance, with benefits dependent on timing and duration of deprivation.

This study shows that the D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice by disrupting nuclear-cytosolic Ca2+ coupling.

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

This study examines how phosphorylation of RyR2 affects dyad size and tetramer arrangement in response to isoproterenol using mutant mice.

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

This study shows that inhibiting DPP-4 and NEP in mice improves the detection of intact GLP-1 using commercial ELISA kits, but may affect metabolic outcomes.

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

This study investigates whether renal-derived human sPRR affects blood pressure and kidney function in obese mice, finding no overall effect but sex-specific differences in male mice.

This paper demonstrates that AAV-mediated delivery of PKP2a gene therapy arrests ARVC progression and prolongs survival in PKP2-deficient mice.

This study shows that loss of CTRP10 in female mice leads to obesity without metabolic complications, highlighting a sex-dependent role in metabolic health.

The paper identifies weaning body weight as a key predictor of adult diabetes in TALLYHO/JngJ mice, highlighting its relevance to childhood obesity research.

The paper compares volume and surface area estimates of erythrocytes using three geometric models to those measured directly.

This study examines how acute stress affects working memory in pilots under varying memory loads, finding an interaction where stress may improve accuracy in moderate loads.

The paper identifies exceptionally long-lived macromolecules in mammalian ovaries and oocytes that contribute to reproductive health across the lifespan.

This study shows heat stress disrupts acid-base homeostasis in the sea anemone Exaiptasia diaphana regardless of symbiont presence, indicating climate change impacts beyond bleaching.

This study investigates how auditory midbrain and cortex process statistical features of natural sound textures using texture morph stimuli in anesthetized rats, finding that the midbrain encodes these features more effectively than the cortex.