E. Tran

Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells

This study shows auranofin induces ROS-mediated apoptosis in HGSOC cells, which can be enhanced by L-BSO through synergistic ROS and GSH depletion.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification

The paper uses multiomic single-cell profiling to show MPAL blasts have a stem-like transcriptional profile linked to poor prognosis and develops a gene score for clinical risk stratification.

Phyllosphere fungal diversity generates pervasive non-additive effects on plant performance

The paper investigates how fungal diversity in the phyllosphere affects plant productivity through non-additive microbial interactions, finding synergistic and antagonistic effects across diverse communities.

A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

This paper introduces a rapid and universal LC-MS-based platform for quantifying monoclonal antibodies, offering a scalable alternative to traditional ligand binding assays.

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

The paper develops novel immortalized human alveolar epithelial cell lines that can form organoids and exhibit lineage memory, offering a new in vitro model for distal lung biology and disease.

Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model

This study investigates how a myocardial matrix hydrogel reduces negative left ventricular remodeling in chronic myocardial infarction by modulating immune response and gene expression.

Profiling grapevine trunk pathogens in planta: A case for community-targeted DNA metabarcoding

This study develops and validates GTAA primers for DNA metabarcoding to accurately detect grapevine trunk pathogens in planta, showing improved sensitivity and specificity over universal primers.