A. Koh

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification

The paper uses multiomic single-cell profiling to show MPAL blasts have a stem-like transcriptional profile linked to poor prognosis and develops a gene score for clinical risk stratification.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

The paper shows that gut bacteria can survive antibiotic treatment without developing resistance by acquiring mutations that enhance their ability to persist and invade intestinal cells.

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

An actin-like filament from Clostridium botulinum exhibits a novel mechanism of filament dynamics

The paper identifies a ParM protein from Clostridium botulinum that forms a double-stranded filament with unique dynamics involving Pi-induced lateral shifts and distinct interactions with ParR.

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Immune checkpoint blockade therapy promotes gut microbiota translocation into secondary lymphoid organs, enhancing extraintestinal anti-tumor immunity.

The composition and function of Enterococcus faecalismembrane vesicles

This study identifies and functionally characterizes membrane vesicles from Enterococcus faecalis, revealing unique lipid and protein profiles and their potential role in virulence.

Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance

The paper shows how the histidine kinase BceS of Bacillus subtilis is controlled by its cognate ABC-transporter to enable energy-efficient antibiotic resistance activation based on need.

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

The C-Terminal Domain Of ParB Is Critical For Dynamic DNA Binding And Bridging Interactions Which Condense The Bacterial Centromere

This study identifies the C-terminal domain of ParB as critical for DNA binding and bridging interactions that drive bacterial chromosome condensation.