Y. Modis

Structure and methyl-lysine binding selectivity of the HUSH complex subunit MPP8

This study reports the crystal structure of MPP8's C-terminal domain and its interaction with HUSH complex components, revealing its role in recruiting H3K9 methyltransferases to promote heterochromatinization.

Crystal structure and biochemical activity of the macro domain from rubella virus p150

This study reports the crystal structure and biochemical activity of the macro domain from rubella virus p150, showing it binds ADP-ribose and has mono-ADP-ribosylhydrolase activity.

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

This study investigates how ATP hydrolysis by MDA5 and LGP2 influences viral RNA sensing, showing MDA5's selectivity and LGP2's role in modulating MDA5 filament assembly.

Structure and functional mapping of the KRAB-KAP1 repressor complex

The paper identifies and validates the molecular interface between KRAB and KAP1, showing its role in TE silencing and gene repression.

The Vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

This study shows that the vaccinia virus D8 protein drives host membrane curvature to facilitate fusion by guiding virion binding orientation and promoting membrane invagination.

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

The paper uses cryo-electron tomography to reveal the ultrastructure of ASC specks and gasdermin D pores in NLRP3-activated cells.

MDA5 autoimmune disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA

This study shows how the MDA5 variant M854K impairs ATP-dependent RNA discrimination, leading to autoimmune disease by allowing misrecognition of endogenous RNAs.

Periphilin self-association underpins epigenetic silencing by the HUSH complex

This study identifies the physicochemical properties of Periphilin required for HUSH complex assembly and epigenetic silencing, showing its N-terminal domain drives aggregation and repressive mark deposition.

Structure of the tripartite motif of KAP1/TRIM28 identifies molecular interfaces required for transcriptional silencing of retrotransposons

This study identifies molecular interfaces in KAP1's RBCC motif critical for self-association and KRAB binding, essential for retrotransposon silencing.

An equilibrium binding model for CpG DNA-dependent dimerization of Toll-like receptor 9

This study develops a theoretical equilibrium binding model to explain how CpG DNA induces TLR9 dimerization, using experimental data from light scattering and fluorescence polarization assays.

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

CryoEM structures of MDA5-dsRNA filaments at different stages of ATP hydrolysis

This paper determines cryoEM structures of MDA5-dsRNA filaments at different ATP hydrolysis stages, revealing how ATPase activity influences filament twist, RNA binding, and signaling.

Neuropathic mutations in MORC2 perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

This study investigates how neuropathic mutations in MORC2 disrupt dimerization dynamics and epigenetic silencing through structural changes in the ATPase module.