R. Dai

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Linalool's Multifaceted Antimicrobial Potential: Unveiling its Antimicrobial Efficacy and Immunomodulatory Role Against Saprolegnia parasitica

This study investigates linalool's antimicrobial and immunomodulatory effects against S. parasitica, showing it disrupts cell membranes, inhibits protein synthesis, and enhances host immune responses.

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2+ macrophages and CD8 T-cells

This study shows CD40 agonists promote myocardial inflammation by activating CCR2+ macrophages and CD8 T-cells, leading to heart failure.

Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana

This study shows that aliphatic aldoximes repress phenylpropanoid production and that altered methionine metabolism affects plant growth and development in Arabidopsis.

The translational role of SOS1 in colorectal cancer

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

SbCYP79A61 Produces Phenylacetaldoxime, a Precursor of Benzyl Cyanide and Phenylacetic Acid in Sorghum bicolor

This study identifies SbCYP79A61 as an enzyme in sorghum that produces phenylacetaldoxime and shows benzyl cyanide as an intermediate in its biosynthesis pathway.

V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity

Gammadelta T Cells Are Required for CD8+ T Cell Response to Vaccinia Viral Infection

This paper shows that gammadelta T cells are essential for activating CD8+ T cells during Vaccinia virus infection through the MyD88 pathway.