Author

A. B. Farris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. B. Adams· 1 shared A. M. Major· 1 shared A. N. Ruggieri· 1 shared B. El-Rayes· 1 shared B. P. Lovasik· 1 shared C. M. Paulos· 1 shared C. McQuinn· 1 shared C. P. Breeden· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. B. Adams

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1

I. Ates, T. Rathbone, C. Stuart, M. Barzi, G. He, A. M. Major, S. Srinivasan, A. B. Farris, K.-D. Bissig, R. N. Cottle

This study develops an ex vivo CRISPR gene editing protocol for hepatocytes to treat hereditary tyrosinemia type 1, showing successful engraftment and disease correction in mice.

bioRxiv · Sep 4, 2023Bioengineering

CD28-Selective Inhibition Prolongs Non-Human Primate Kidney Transplant Survival

B. P. Lovasik, S. C. Kim, L. Higginbotham, W. Wakwe, D. V. Mathews, C. P. Breeden, A. B. Farris, C. P. Larsen, M. L. Ford, S. Nadler, A. B. Adams

This study tests a CD28-selective therapy in non-human primates, showing extended kidney transplant survival compared to belatacept alone.

bioRxiv · May 3, 2023 · PreprintImmunology

Virtual Liver Needle Biopsy from Reconstructed Three-Dimensional Histopathological Images: Quantification of Sampling Error

Q. Li, F. Wang, Y. Chen, H. Chen, S. Wu, A. B. Farris, Y. Jiang, J. Kong

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

bioRxiv · Jun 8, 2022Bioengineering

Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T cell-dependent manner.

M. B. Ware, C. McQuinn, M. Y. Zaidi, H. Knochelmann, T. A. Mace, Z. Chen, C. Zhang, M. R. Farren, A. N. Ruggieri, J. Bowers, R. Shakya, A. B. Farris, G. Young, W. E. Carson, B. El-Rayes, , G. B. Lesinski

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

bioRxiv · Feb 7, 2020 · PreprintCancer Biology