M. Wei

A forward-engineered muscle tissue driven soft robotic swimmer

The paper builds a biohybrid robot with muscle-driven tail motion to study swimming dynamics and muscle adaptation, achieving speeds surpassing low-Reynolds number predictions.

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response.

This study identifies that TIS-derived extracellular vesicles suppress breast cancer through DKK1-mediated inflammation, contrasting with the pro-tumorigenic effects of the senescence-associated secretome.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

An exploration of mechanisms underlying Desemzia incerta colonization resistance to methicillin-resistant Staphylococcus aureus on the skin

This study identifies Desemzia incerta as a skin commensal that reduces MRSA colonization through secreted antimicrobial proteins and decreased biofilm formation in a murine model.

YY2/BUB3 axis-mediated SAC hyperactivity determines tumor cell fate through chromosomal instability

This study identifies the YY2/BUB3 axis as a regulator of SAC activity and shows how SAC hyperactivity and CIN levels influence tumor cell fate and drug sensitivity.

Wound microbiota-mediated correction of matrix metalloproteinase expression promotes re-epithelialization of diabetic wounds

This study shows that Alcaligenes faecalis treatment corrects matrix metalloproteinase overexpression in diabetic wounds, promoting re-epithelialization.

Cell arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms

Harnessing Nature's nanoSecrets: biocompatibility, biodistribution and bioactivity of extracellular vesicles derived from microalgae

This study evaluates the biocompatibility, biodistribution, and bioactivity of microalgae-derived extracellular vesicles in preclinical models.

Mitochondrial genome evolution in the Diprionidae: Major gene rearrangement in the basal Hymenoptera

The paper examines mitochondrial gene rearrangements in Diprionidae, showing their potential as phylogenetic markers in Hymenoptera evolution.

Spatial heterogeneity in biofilm metabolism elicited by local control of phenazinemethylation

This study shows that Pseudomonas aeruginosa uses global regulators RpoS and Hfq/Crc to control methylated phenazine production, balancing their toxic and beneficial effects in biofilms.

MIIP downregulation promotes colorectal cancer progression via inducing adjacent adipocytes browning

This study shows MIIP downregulation in colorectal cancer promotes tumor progression by inducing adjacent adipocytes to brown, releasing free fatty acids that fuel cancer growth.

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties

This study identifies PLOD2 as a key factor mediating the chondroprotective and metabolic properties of MRL mouse MSCs in an OA model.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus

The paper identifies novel microbiota-mediated mechanisms of colonization resistance to MRSA in pig skin using a swine model and isolates.

Characterization of pyridomycin B reveals the formation of functional groups in antimycobacterial pyridomycin

This study characterizes pyridomycin B, a pyridomycin analogue, revealing that Pyr2 catalyzes ketoreduction and double bond formation in a unique energy-saving manner, contributing to the formation of functional groups in pyridomycin.

A H3K9me2-Binding Protein AGDP3 Limits DNA Methylation and Transcriptional Gene Silencing in Arabidopsis

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor

TSG Targeting KDM5A affects osteogenic differentiation of bone mesenchymal stem cells induced by bone morphogenetic protein 2

This study investigates how TSG promotes osteogenic differentiation of BMSCs by inhibiting KDM5A expression.

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

Fructose Metabolism Contributes to the Warburg effect

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

The paper determines cryo-EM structures of human TRPC5 channel with two inhibitors, revealing their distinct binding sites and mechanisms of action.

Protein Tyrosine Phosphatase 4A3 (PTP4A3) modulates Src signaling in T-cell Acute Lymphoblastic Leukemia to promote leukemia migration and progression

This study identifies PTP4A3 as an oncogenic driver in T-ALL that promotes migration and progression through modulation of SRC signaling.

NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and Tumorigenesis

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

Optical Imaging of Metabolic Dynamics in Animals

This paper introduces DO-SRS, a method to visualize metabolic dynamics in living tissues by imaging deuterium incorporation into macromolecules.