A. Ng

Degradome analysis to identify direct protein substrates of small-molecule degraders

The paper introduces a method to identify direct protein substrates of small-molecule degraders using degradome analysis and mass spectrometry.

Life stage impact on the human skin ecosystem: lipids and the microbial community

The paper investigates how life stages affect the human skin microbiome and lipid mediators, finding microbial correlations with lipid profiles and cytokine production.

Size photometry and fluorescence imaging of immobilized immersed extracellular vesicles

This paper introduces a label-free method for measuring extracellular vesicle size and integrates it with fluorescence imaging using interferometric scattering.

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer

This study introduces gravity-based microfiltration to isolate CTC clusters, finding they are prevalent in ovarian and colorectal cancer patients.

Effect of sample preprocessing and extraction methods on the physical and molecular profiles of extracellular vesicles

This study compares EV extraction methods and preservation agents, finding method-specific differences in yield, purity, and protein profiles.

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA enables high-throughput, high-plex protein profiling of the inflammatory secretome, revealing 447 significant cytokine responses across multiple donors and conditions.

Microfluidics on Stretchable Strings

This paper introduces string microfluidics, a new microfluidic approach that enables droplet operations through stretchable strings and is compatible with colorimetric assays.

3D-printed capillaric ELISA-on-a-chip with aliquoting

This paper introduces a 3D-printed ELISA-on-a-chip with aliquoting functionality that eliminates the need for precise pipetting and enables high-sensitivity detection of SARS-CoV-2 nucleocapsid protein in diluted saliva.

Belowground plant responses to root herbivory depend on the composition and structure of their root-colonising arbuscular mycorrhizal fungi

This study shows that Sorghum bicolor's response to root herbivory varies with the composition and structure of its root-colonising arbuscular mycorrhizal fungal communities.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Mechanically Matched Silicone Brain Implants Reduce Brain Foreign Body Response

This study introduces mechanically matched silicone brain implants that reduce the foreign body response compared to traditional implants.

Global Genetic Cartography of Urban Metagenomes andAnti-Microbial Resistance

The paper creates a global metagenomic atlas of urban microbial ecosystems, identifying novel species and geographic variation in antimicrobial resistance genes.

Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA

This study develops a method to efficiently generate human-induced pluripotent stem cell-derived endothelial cells by modulating ETV2 with modified mRNA, achieving high consistency and functionality.

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

The paper shows that autoinhibition of kinesin-1 is crucial for dendrite-specific Golgi outpost localization, preventing their mislocalization to axons.

Genome-Scale Mutational Signatures Of Aflatoxin In Cells, Mice And Human Tumors

This study identifies AFB1 mutational signatures across multiple systems and shows their prevalence in HCCs from different regions, highlighting aflatoxin's public health impact.