Author

A. Bertoletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Chia· 5 shared A. T. Tan· 5 shared K. Kunasegaran· 5 shared N. Le Bert· 5 shared L.-F. Wang· 4 shared J. G. Low· 3 shared N. Tan· 3 shared S. Kalimuddin· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersImmunology

A. Chia

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mutations of SARS-CoV-2 variants of concern escaping Spike-specific T cells

N. Le Bert, A. T. Tan, K. Kunasegaran, A. Chia, N. Tan, Q. Chen, S. K. Hang, M. D. Qui, B. S. Chan, J. G. Low, B. Young, K. C. Ng, D. W. S. Chan, D. C. B. Lye, A. Bertoletti

This study examines how mutations in SARS-CoV-2 variants affect Spike-specific T cell responses, finding that some mutations reduce CD8 T cell recognition while overall T cell responses remain largely intact.

bioRxiv · Jan 20, 2022 · PreprintImmunology

Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected

A. T. Tan, J. M. Lim, N. Le Bert, K. Kunasegaran, A. Chia, M. Qui, N. Tan, W. N. Chia, R. Alwis, Y. Ding, E. E. Ooi, L.-F. Wang, M. I. Chen, B. Young, L. Y. Hsu, , A. Bertoletti

This study evaluates a rapid whole blood test for measuring SARS-CoV-2 Spike-specific T cell responses in vaccinated and infected individuals, finding a wide dynamic range independent of neutralizing antibodies.

bioRxiv · Jun 29, 2021 · PreprintImmunology

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals

C. Camara, D. Lozano-Ojalvo, E. Lopez-Granados, E. Paz-Artal, M. Pion, R. Correa-Rocha, A. Ortiz, M. Lopez-Hoyos, M. Erro Iribarren, J. Portoles, P. Portoles, M. Perez-Olmeda, J. Oteo-Iglesias, C. Berin, E. Guccione, , J. Ochando

This study examines how the second dose of the BNT162b2 vaccine affects T cell immunity in naive and previously infected individuals, finding reduced cellular immunity in recovered individuals.

bioRxiv · Mar 22, 2021Immunology

Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses

C. C. S. Tan, C. J. Owen, C. Y. L. Tham, A. Bertoletti, L. van Dorp, F. Balloux

bioRxiv · Dec 8, 2020Immunology

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

N. Le Bert, H. E. Clapham, A. T. Tan, W. N. Chia, C. Y. Tham, J. M. Lim, K. Kunasegaran, L. Tan, C.-A. Dutertre, N. Shankar, J. M. Lim, L. J. Sun, M. Zahari, Z. M. Tun, V. Kumar, , C. C. Tam

This study compares T cell responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that asymptomatic individuals have a robust and functional immune response with balanced cytokine production.

bioRxiv · Nov 25, 2020Immunology

Early induction of SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

A. T. Tan, M. Linster, C. Tan, N. Le Bert, W. Chia, K. Kunasegaran, Y. Zhuang, C. Y. Tham, A. Chia, G. J. Smith, B. E. Young, S. Kalimuddin, J. G. Low, D. Lye, L.-F. Wang, A. Bertoletti

The paper examines the relationship between SARS-CoV-2 specific T cell responses and disease severity in COVID-19 patients, finding that early T cell induction correlates with mild disease and faster viral clearance.

bioRxiv · Oct 15, 2020Immunology

Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals

N. Le Bert, A. T. Tan, K. Kunasegaran, C. Y. L. Tham, M. Hafezi, A. Chia, M. Chng, M. Lin, N. Tan, M. Linster, W. N. Chia, M. I.-C. Chen, L.-F. Wang, E. E. Ooi, S. Kalimuddin, , A. Bertoletti

The paper compares pre-existing SARS-CoV-2 specific T cell immunity in SARS-recovered and uninfected individuals, finding differential T cell immunodominance patterns.

bioRxiv · May 26, 2020Immunology