Author

E. E. Ooi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bertoletti· 2 shared A. Chia· 2 shared A. T. Tan· 2 shared E. S. Gan· 2 shared H. C. Tan· 2 shared K. Kunasegaran· 2 shared L.-F. Wang· 2 shared M. M. Choy· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

A. Bertoletti

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

M. G. Bigotti, K. Klein, E. S. Gan, M. Anastasina, S. Andersson, O. Vapalahti, P. Katajisto, M. Erdmann, A. D. Davidson, S. J. Butcher, I. Collinson, E. E. Ooi, G. Balistreri, A. Brancaccio, Y. Yamauchi

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

bioRxiv · Nov 6, 2023Microbiology

Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

B. L. A. Chew, A. Q. Ngoh, W. W. Phoo, W. K. K. Chan, S. Zheng, N. K. Tulsian, S. S. Lim, M. J. G. Weng, S. Watanabe, M. M. Choy, G. H. J. Low, E. E. Ooi, C. Ruedl, R. M. SOBOTA, S. G. Vasudevan, D. Luo

The paper determines the structure of secreted dengue virus NS1 from infected cells, showing it forms dimers complexed with HDL.

bioRxiv · Apr 6, 2022Microbiology

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

T. Singh, K.-K. Hwang, A. S. Miller, R. L. Jones, C. A. Lopez, C. Giuberti, M. A. Gladden, I. Miller, H. S. Webster, J. A. Eudailey, K. Luo, T. Von Holle, R. J. Edwards, S. Valencia, K. E. Burgomaster, , M. Bonsignori

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

bioRxiv · Nov 23, 2021Immunology

Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected

A. T. Tan, J. M. Lim, N. Le Bert, K. Kunasegaran, A. Chia, M. Qui, N. Tan, W. N. Chia, R. Alwis, Y. Ding, E. E. Ooi, L.-F. Wang, M. I. Chen, B. Young, L. Y. Hsu, , A. Bertoletti

This study evaluates a rapid whole blood test for measuring SARS-CoV-2 Spike-specific T cell responses in vaccinated and infected individuals, finding a wide dynamic range independent of neutralizing antibodies.

bioRxiv · Jun 29, 2021 · PreprintImmunology

Cell strain-derived induced pluripotent stem cell as a genetically controlled approach to investigating aging mechanisms and viral pathogenesis

a. M. Bifani, H. C. Tan, M. M. Choy, E. E. Ooi

This study uses iPSC-derived cell strains to investigate how aging impacts dengue virus-host interactions and pathogenesis.

bioRxiv · May 11, 2021 · PreprintMicrobiology

A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice

R. M. de Alwis, E. S. Gan, S. Chen, Y. S. Leong, H. C. Tan, S. L. Zhang, C. Yau, D. Matsuda, E. Allen, P. Hartman, J. Park, M. Alayyoubi, H. Bhaskaran, A. Dukanovic, B. Bao, , E. E. Ooi

A single dose of the STARR-based SARS-CoV-2 vaccine LUNAR-COV19 induces protective adaptive immunity in mice, including strong antibody and CD8+ T cell responses, and full protection against viral challenge.

bioRxiv · Sep 3, 2020Immunology

Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals

N. Le Bert, A. T. Tan, K. Kunasegaran, C. Y. L. Tham, M. Hafezi, A. Chia, M. Chng, M. Lin, N. Tan, M. Linster, W. N. Chia, M. I.-C. Chen, L.-F. Wang, E. E. Ooi, S. Kalimuddin, , A. Bertoletti

The paper compares pre-existing SARS-CoV-2 specific T cell immunity in SARS-recovered and uninfected individuals, finding differential T cell immunodominance patterns.

bioRxiv · May 26, 2020Immunology

Evolution of subgenomic RNA shapes dengue virus adaptation and epidemiological fitness

E. Finol, E. E. Ooi

This study shows that mutations in the 3UTR of DENV-2 affect sfRNA structure and epidemiological fitness through positive selection on specific RNA elements.

bioRxiv · Nov 28, 2018Microbiology