S. G. Rozen

The paper examines genomic and transcriptomic changes in NSRO-driven NSCLCs in smokers and non-smokers, finding no smoking-induced mutations but higher transcriptomic cell cycle activity in smokers.

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

This study identifies the mutational signature of cisplatin in human cell lines and tumors, enabling detection of cisplatin exposure in hepatocellular and esophageal cancers.