Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis
M. Engevik, L. Guo, W.-S. Song, C. Chronowski, V. Akhanov, N. Bosquez, A. Engevik, N. Oezguen, C. Coarfa, N. Putluri, A. Catic, J. Baur, M. Finegold, N. Shroyer, J. Gu, , E. Sahin
This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.
bioRxiv · Jul 14, 2022 · PreprintCell Biology